| Description | Mouse Striatal Neurons (MStN) are derived from striatum of day 18 embryonic CD1 mouse brain. When cultured under the recommended conditions, MStN arborize and form complex neurite network in one week. MStN Stain positive for β III-Tubulin.
The striatum is a subcortical part of the forebrain. ItMouse Striatal Neurons (MStN) are derived from striatum of day 18 embryonic CD1 mouse brain. When cultured under the recommended conditions, MStN arborize and form complex neurite network in one week. MStN Stain positive for β III-Tubulin.
The striatum is a subcortical part of the forebrain. It receives and processes input signals from different parts of the cerebral cortex. With its robust interactions among cholinergic, dopaminergic, and GABAergic neurotransmitter systems, striatum plays a key role in voluntary movement, reward-based habit learning, addiction, procedural memory formation, and cognitive dysfunctions in Parkinson's disease. Studies using striatal neurons will allow a better understanding of the striatal-related functions and diseases. Cultures of striatal neurons can be applied for a variety of experiments including toxicity test, immunostaining, live cell imaging, co-culturing, electrophysiology, and more.... Read More | Cynomolgus monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus monkey lymph node tissue.Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of tests and assays such as Cynomolgus monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus monkey lymph node tissue.Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of tests and assays such as cell-cell interaction, adhesion, migration, PCR, Western blot, immunoprecipitation, immunofluorescent staining, immunofluorescent flow cytometry, or generating cell derivatives for desired research applications.... Read More | Creative Biolabs' Alzheimer's Disease Brain Tissue Panel (TeHAD-Alz) is designed to rapidly screen brain tissue for Alzheimer's disease-specific genes or proteins. | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in autosomal-dominant familial Parkinson's disease with late onset (Fonzo et al., 2006, Thaler et al., 2009). The G2019S mutation increases the kinase activity of LRRK2 causing increased autophosphorylation and substrate phosphorylation that may affect neuronal cell health in Parkinson's disease patients (West et al., 2005).... Read More | The product SIRGT77459WQ-2F is a type of small interfering RNA (siRNA) that targets MAT2B gene and regulates the expression gene. The siRNA interferes with the expression MAT2B gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is The product SIRGT77459WQ-2F is a type of small interfering RNA (siRNA) that targets MAT2B gene and regulates the expression gene. The siRNA interferes with the expression MAT2B gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2_-deoxy-2_-fluoro (2'-F) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More |