| Description | Mouse Striatal Neurons (MStN) are derived from striatum of day 18 embryonic CD1 mouse brain. When cultured under the recommended conditions, MStN arborize and form complex neurite network in one week. MStN Stain positive for β III-Tubulin.
The striatum is a subcortical part of the forebrain. ItMouse Striatal Neurons (MStN) are derived from striatum of day 18 embryonic CD1 mouse brain. When cultured under the recommended conditions, MStN arborize and form complex neurite network in one week. MStN Stain positive for β III-Tubulin.
The striatum is a subcortical part of the forebrain. It receives and processes input signals from different parts of the cerebral cortex. With its robust interactions among cholinergic, dopaminergic, and GABAergic neurotransmitter systems, striatum plays a key role in voluntary movement, reward-based habit learning, addiction, procedural memory formation, and cognitive dysfunctions in Parkinson's disease. Studies using striatal neurons will allow a better understanding of the striatal-related functions and diseases. Cultures of striatal neurons can be applied for a variety of experiments including toxicity test, immunostaining, live cell imaging, co-culturing, electrophysiology, and more.... Read More | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | This product is a 64.0kDa Human DSG3 membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis. | Recombinant O'nyong'nyong Virus-like Particles (ONNV VLPs) are produced in mammalian HEK293 human cells, assembled with E1, E2 and Capsid proteins. VLP is mimicking the native 3D structure of viruses which can elicit strong immune responses. However, VLPs lack viral genomic material which makes themRecombinant O'nyong'nyong Virus-like Particles (ONNV VLPs) are produced in mammalian HEK293 human cells, assembled with E1, E2 and Capsid proteins. VLP is mimicking the native 3D structure of viruses which can elicit strong immune responses. However, VLPs lack viral genomic material which makes them non-infectious, unable to replicate and enhance the safety during manufacture and administration. ONNV VLPs can be used in the development of ONNV diagnostics and in vaccine development and R&D (including use as an immunogen).... Read More | Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to the human anatomically and physiologically. This product is isolated from Rhesus monkeys Peripheral Nerve Tissue. The sample is negative for Herpes-B Virus, Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to the human anatomically and physiologically. This product is isolated from Rhesus monkeys Peripheral Nerve Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of tests and assays such as PCR, Western blot, immunoprecipitation, immunofluorescent flow cytometry.... Read More |