| Description | Faecalibacterium is a genus of bacteria. Its sole known species, Faecalibacterium prausnitzii is a Gram-positive, mesophilic, rod-shaped, anaerobic and is one of the most abundant and important commensal bacteria of the human gut microbiota. Faecalibacterium prausnitzii is an extremely oxygen Faecalibacterium is a genus of bacteria. Its sole known species, Faecalibacterium prausnitzii is a Gram-positive, mesophilic, rod-shaped, anaerobic and is one of the most abundant and important commensal bacteria of the human gut microbiota. Faecalibacterium prausnitzii is an extremely oxygen sensitive; EOS bacterium and is difficult to cultivate even in anaerobic conditions and widely distributed in the Gastrointestinal Tract; GIT of other mammals such pigs, mice and calves as well as poultry, and the insect cockroach. Changes in the abundance of fecal Clostridium leptum group, and in particular Faecalibacterium prausnitzii, have been extensively described in different human intestinal and metabolic diseases. Faecalibacterium prausnitzii is a butyrate producer and has demonstrated anti-inflammatory effects in vitro and in vivo using a mouse colitis model making it a key member of the microbiota that may contribute to intestinal homeostasis. Thus, modulation of Faecalibacterium prausnitzii abundance, for example using prebiotics and/or probiotics and/or formulations that permit survival through the upper part of the intestinal tract might have prophylactic or therapeutic applications in human health.... Read More | Recombinant Ebola Virus-like Particles (EBOV VLPs) are produced in mammalian HEK293 human cells, assembled with Nucleoprotein, Glycoprotein and Matrix protein. VLP is mimicking the native 3D structure of viruses which can elicit strong immune responses. However, VLPs lack viral genomic material Recombinant Ebola Virus-like Particles (EBOV VLPs) are produced in mammalian HEK293 human cells, assembled with Nucleoprotein, Glycoprotein and Matrix protein. VLP is mimicking the native 3D structure of viruses which can elicit strong immune responses. However, VLPs lack viral genomic material which makes them non-infectious, unable to replicate and enhance the safety during manufacture and administration. EBOV VLPs can be used in the development of EBOV diagnostics and in vaccine development and R&D (including use as an immunogen).... Read More | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | Rat Schwann cells (RSC) are the main glial cells in the peripheral nervous system, providing physical and chemical support for neurons. Myelin Schwann cells form an insulating sheath around neuron cell bodies (sensory ganglia) and fibers (sensory nerves and motor neurons). Regular exposure of the Rat Schwann cells (RSC) are the main glial cells in the peripheral nervous system, providing physical and chemical support for neurons. Myelin Schwann cells form an insulating sheath around neuron cell bodies (sensory ganglia) and fibers (sensory nerves and motor neurons). Regular exposure of the axon membrane to the extracellular space (myelin sheath space) at the Raniver node allows the action potential to propagate quickly along the axon. RSC is important for the morphology, survival and growth of axons and neurons. Studies have also shown that Schwann cells can promote neuronal recovery and experimental spinal cord regeneration.... Read More | Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to humans anatomically and physiologically. This product is purified from Rhesus monkey PBMCs by magnetic selection. Cells are negative for bacteria, yeast, Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to humans anatomically and physiologically. This product is purified from Rhesus monkey PBMCs by magnetic selection. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of tests and assays such as cell-cell interaction, adhesion, migration, PCR, Western blot, immunoprecipitation, immunofluorescent staining, immunofluorescent flow cytometry, or generating cell derivatives for desired research applications.... Read More |