| Description | Creative Biolabs offers a range of recombinant cell lines for Immunotherapy discovery and development. | Human astrocytes (HA) are derived from the human cerebral cortex. Astrocytes are the most abundant cells in the central nervous system, where they perform many functions, such as providing mechanical support and nutrition to neurons and removing waste from neurons. Provide signals to endothelial Human astrocytes (HA) are derived from the human cerebral cortex. Astrocytes are the most abundant cells in the central nervous system, where they perform many functions, such as providing mechanical support and nutrition to neurons and removing waste from neurons. Provide signals to endothelial cells; regulate neurogenesis and control synaptic function. With the increasing understanding of the importance of astrocytes in the nervous system, HA has become a useful in vitro model for exploring the functional diversity of astrocytes.... Read More | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in autosomal-dominant familial Parkinson's disease with late onset (Fonzo et al., 2006, Thaler et al., 2009). The G2019S mutation increases the kinase activity of LRRK2 causing increased autophosphorylation and substrate phosphorylation that may affect neuronal cell health in Parkinson's disease patients (West et al., 2005).... Read More | This product is a 43.2 kDa Human GRPR membrane protein expressed in in vitro wheat germ expression system with proprietary liposome technology. The protein is for research use only and is not approved for use in humans or in clinical diagnosis. | The product SIRGT65419WQ is a type of small interfering RNA (siRNA) that targets CASTOR1 gene and regulates the expression of gene. The siRNA interferes with the expression of CASTOR1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has The product SIRGT65419WQ is a type of small interfering RNA (siRNA) that targets CASTOR1 gene and regulates the expression of gene. The siRNA interferes with the expression of CASTOR1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More |