| Description | This product is a Rat factor H protein which is purified from rat serum. It is an essential regulatory component of the alternative pathway of complement. It has two functional activities: 1) it controls the formation and decay of the alternative pathway C3/C5 convertase (decay accelerating activityThis product is a Rat factor H protein which is purified from rat serum. It is an essential regulatory component of the alternative pathway of complement. It has two functional activities: 1) it controls the formation and decay of the alternative pathway C3/C5 convertase (decay accelerating activity) and 2) it acts as a cofactor for factor I which proteolytically inactivates C3b when C3b is bound to factor H (cofactor activity).... Read More | Human astrocytes (HA) are derived from the human cerebral cortex. Astrocytes are the most abundant cells in the central nervous system, where they perform many functions, such as providing mechanical support and nutrition to neurons and removing waste from neurons. Provide signals to endothelial Human astrocytes (HA) are derived from the human cerebral cortex. Astrocytes are the most abundant cells in the central nervous system, where they perform many functions, such as providing mechanical support and nutrition to neurons and removing waste from neurons. Provide signals to endothelial cells; regulate neurogenesis and control synaptic function. With the increasing understanding of the importance of astrocytes in the nervous system, HA has become a useful in vitro model for exploring the functional diversity of astrocytes.... Read More | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | Lactobacillus species are normal flora of the human mouth, gastrointestinal tract, and female genital tract, where they produce lactic acid and competitively inhibit pathogenic organisms. Lactobacillus are small, slender, nonmotile, Gram-positive bacilli in chains. Immature colonies appear smooth, Lactobacillus species are normal flora of the human mouth, gastrointestinal tract, and female genital tract, where they produce lactic acid and competitively inhibit pathogenic organisms. Lactobacillus are small, slender, nonmotile, Gram-positive bacilli in chains. Immature colonies appear smooth, convex, and translucent. Some species of Lactobacillus used commonly as probiotics. They are most commonly used for diarrhea, including infectious diarrhea and diarrhea in people taking antibiotics. Some people also use lactobacillus for general digestion problems, irritable bowel syndrome; IBS, colic in infants, and many other conditions that involve the stomach and bowel.... Read More | This product is a 21.4kDa recombinant mouse Ficolin 2 protein with a N-terminal His Tag tag expressed in the E.coli. It is availible for Positive Control, Immunogen, WB. |