| Quantity | 20 nmol, 50 nmol, 100 nmol, 200 nmol | 1.5 million cells & Neural Plating-XF Medium | 2 vials | 2 vials | 20 nmol, 50 nmol, 100 nmol, 200 nmol |
| Description | The product SIRGT00486WQ is a type of small interfering RNA (siRNA) that targets C5AR1 gene and regulates the expression of gene. The siRNA interferes with the expression of C5AR1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has The product SIRGT00486WQ is a type of small interfering RNA (siRNA) that targets C5AR1 gene and regulates the expression of gene. The siRNA interferes with the expression of C5AR1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | Creative Biolabs offers the overexpression cell line which expressing the co-inhibitory and co-stimulatory immune checkpoints of human, mouse and cynomolgus monkey origin to accelerate immunotherapy discovery and development. | Creative Biolabs offers a range of recombinant cell lines for Immunotherapy discovery and development. | The product SIRGT95067WQ is a type of small interfering RNA (siRNA) that targets Coq4 gene and regulates the expression of gene. The siRNA interferes with the expression of Coq4 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has The product SIRGT95067WQ is a type of small interfering RNA (siRNA) that targets Coq4 gene and regulates the expression of gene. The siRNA interferes with the expression of Coq4 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More |