| Description | Creative Biolabs offers the overexpression Raji cells that stably express immune checkpoints. | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the G2019S mutation (GGC>AGC) in the LRRK2 gene. This line is homozygous for the G2019S mutation so both alleles contain the mutation.
The G2019S mutation in LRRK2 has been implicated in autosomal-dominant familial Parkinson's disease with late onset (Fonzo et al., 2006, Thaler et al., 2009). The G2019S mutation increases the kinase activity of LRRK2 causing increased autophosphorylation and substrate phosphorylation that may affect neuronal cell health in Parkinson's disease patients (West et al., 2005).... Read More | Creative Biolabs offers the overexpression cell line which expressing the co-inhibitory and co-stimulatory immune checkpoints of human, mouse and cynomolgus monkey origin to accelerate immunotherapy discovery and development. | This product is a 40.8 kDa Human CCR8 membrane protein expressed in Baculovirus/Insect expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis. | Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to the human anatomically and physiologically. This product is isolated from Rhesus monkeys Peripheral Nerve Tissue. The sample is negative for Herpes-B Virus, Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to the human anatomically and physiologically. This product is isolated from Rhesus monkeys Peripheral Nerve Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of tests and assays such as PCR, Western blot, immunoprecipitation, immunofluorescent flow cytometry.... Read More |