| Description | The product SIRGT43037WQ-2MOE is a type of small interfering RNA (siRNA) that targets TSPAN12 gene and regulates the expression of gene. The siRNA interferes with the expression of TSPAN12 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. TheThe product SIRGT43037WQ-2MOE is a type of small interfering RNA (siRNA) that targets TSPAN12 gene and regulates the expression of gene. The siRNA interferes with the expression of TSPAN12 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2'-O-methoxyethyl (2'-MOE) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More | Baboon are large, robust, and primarily terrrestrial monkeys with orthographic processing abilities. This product is isolated from Baboons Epidermis Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of tests and assays such as PCR, Western Baboon are large, robust, and primarily terrrestrial monkeys with orthographic processing abilities. This product is isolated from Baboons Epidermis Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of tests and assays such as PCR, Western blot, immunoprecipitation, immunofluorescent flow cytometry.... Read More | Researchers at the Creative Biolabs have developed BALB/c Mouse PBMCs that allows for study in numerous research areas, such as immunology, oncology. The cells can be used for a wide variety of safety assessment and functional assays. | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | Creative Biolabs offers a range of recombinant cell lines for Immunotherapy discovery and development. |