| Description | The product SIRGT98134WQ-2MOE is a type of small interfering RNA (siRNA) that targets Mavs gene and regulates the expression of gene. The siRNA interferes with the expression of Mavs gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNAThe product SIRGT98134WQ-2MOE is a type of small interfering RNA (siRNA) that targets Mavs gene and regulates the expression of gene. The siRNA interferes with the expression of Mavs gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2'-O-methoxyethyl (2'-MOE) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More | Cynomolgus Monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus Monkey fresh bone marrow under sterile conditions. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of Cynomolgus Monkey is widely used in medical experiments, especially those associated with neuroscience and disease. This product is isolated from Cynomolgus Monkey fresh bone marrow under sterile conditions. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of applications, including drug discovery, assay validation/development, and immunology based assays.... Read More | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | This product is a 213 kDa recombinant human CD35 protein with a C-terminal 10-His tag expressed in the mouse myeloma cell line, NS0. It is available for Binding Activity Assays. | Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to humans anatomically and physiologically. This product is isolated from tissue of Rhesus monkey. Cells are negative for bacteria, yeast, fungi, mycoplasma, Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to humans anatomically and physiologically. This product is isolated from tissue of Rhesus monkey. Cells are negative for bacteria, yeast, fungi, mycoplasma, and can be used for a variety of tests and assays such as cell-cell interaction, adhesion, migration, PCR, Western blot, immunoprecipitation, immunofluorescent staining, immunofluorescent flow cytometry, or generating cell derivatives for desired research applications.... Read More |