| Description | Faecalibacterium is a genus of bacteria. Its sole known species, Faecalibacterium prausnitzii is a Gram-positive, mesophilic, rod-shaped, anaerobic and is one of the most abundant and important commensal bacteria of the human gut microbiota. Faecalibacterium prausnitzii is an extremely oxygen Faecalibacterium is a genus of bacteria. Its sole known species, Faecalibacterium prausnitzii is a Gram-positive, mesophilic, rod-shaped, anaerobic and is one of the most abundant and important commensal bacteria of the human gut microbiota. Faecalibacterium prausnitzii is an extremely oxygen sensitive; EOS bacterium and is difficult to cultivate even in anaerobic conditions and widely distributed in the Gastrointestinal Tract; GIT of other mammals such pigs, mice and calves as well as poultry, and the insect cockroach. Changes in the abundance of fecal Clostridium leptum group, and in particular Faecalibacterium prausnitzii, have been extensively described in different human intestinal and metabolic diseases. Faecalibacterium prausnitzii is a butyrate producer and has demonstrated anti-inflammatory effects in vitro and in vivo using a mouse colitis model making it a key member of the microbiota that may contribute to intestinal homeostasis. Thus, modulation of Faecalibacterium prausnitzii abundance, for example using prebiotics and/or probiotics and/or formulations that permit survival through the upper part of the intestinal tract might have prophylactic or therapeutic applications in human health.... Read More | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | This product is a 38.6 kDa Human GPR20 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis. | This product is a 51.1 kDa Human RXFP3 membrane protein expressed in Baculovirus/Insect expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis. | This product is a 213 kDa recombinant human CD35 protein with a C-terminal 10-His tag expressed in the mouse myeloma cell line, NS0. It is available for Binding Activity Assays. |