| Quantity | Inquire | Inquire | 1.5 million cells & Neural Plating-XF Medium | 20 nmol, 50 nmol, 100 nmol, 200 nmol | 20 nmol, 50 nmol, 100 nmol, 200 nmol |
| Description | Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to the human anatomically and physiologically. This product is isolated from Rhesus monkeys Skeletal Muscle Tissue. The sample is negative for Herpes-B Virus, Rhesus monkey is widely used in medical and biological research on human and animal related diseases even space travel due to its closeness to the human anatomically and physiologically. This product is isolated from Rhesus monkeys Skeletal Muscle Tissue. The sample is negative for Herpes-B Virus, as well as SRV, SIV, STLV-1, and can be used for a variety of tests and assays such as PCR, Western blot, immunoprecipitation, immunofluorescent flow cytometry.... Read More | Bifidobacterium are Gram-positive, heterofermentative, anaerobic bacteria with a distinctive bifid; i.e. Y shape after which they are named. They wre originally isolated from the faeces of breast-fed infants, members of the genus Bifidobacterium are commonly found in the GI tract of mammals. In Bifidobacterium are Gram-positive, heterofermentative, anaerobic bacteria with a distinctive bifid; i.e. Y shape after which they are named. They wre originally isolated from the faeces of breast-fed infants, members of the genus Bifidobacterium are commonly found in the GI tract of mammals. In humans, Bifidobacterium resides within the GI tract, from birth to old age. Disturbances in the microbiota are linked to an ever-growing number of immune-linked disease states including IBD, atopic allergy, arthritis, and obesity. Therefore, there is a significant interest in treating these diseases through microbial or "probiotic" supplementation of patients, including Bifidobacterium. Data from mouse models and clinical trials indicate that Bifidobacterium may have beneficial effects for treating and preventing immune-linked diseases, including gut-associated and systemic conditions. Bifidobacterium have been commercially exploited as probiotic agents due to their associated health benefits and GRAS; Generally Recognised As Safe status.... Read More | Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the P301L mutation (CCG>CTG) into the MAPT gene. This line is homozygous for the P301L mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The P301L mutation MAPT has been implicated in frontotemporal dementia and parkinsonism (Dumanchin et al., 1998). The mutation affects only the 4R isoforms of MAPT since the exon containing the mutation is spliced out of 3R isoforms (Hutton et al., 1998). Aggregated MAPT/tau protein in affected patients consisted mainly of the 4R isoform (Hutton et al., 1998). The P301L mutation promotes aggregation of MAPT/tau protein into ordered paired helical filaments and beta sheet formation in vitro (von Bergen et al., 2001).... Read More | The product SIRGT99541WQ-LNA is a type of small interfering RNA (siRNA) that targets A2m gene and regulates the expression of gene. The siRNA interferes with the expression of A2m gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA isThe product SIRGT99541WQ-LNA is a type of small interfering RNA (siRNA) that targets A2m gene and regulates the expression of gene. The siRNA interferes with the expression of A2m gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is systematically modified with the synthetic RNA-like high affinity nucleotide analogue, Locked Nucleic Acid (LNA), to improve its bio-stability, specificity and efficiency. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More | The product SIRGT25964WQ is a type of small interfering RNA (siRNA) that targets NRXN3 gene and regulates the expression of gene. The siRNA interferes with the expression of NRXN3 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has The product SIRGT25964WQ is a type of small interfering RNA (siRNA) that targets NRXN3 gene and regulates the expression of gene. The siRNA interferes with the expression of NRXN3 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. It has potential applications in RNA interference (RNAi) and gene therapy development.... Read More |