| Description | Product Introductionrecombinant, expressed in rice, suitable for cell culture, low endotoxin;It is a kind of recombinant human albumin (RHA) without animal origin. It is designed for cell culture applications and is a powerful medium supplement with superior performance to human albumin, bovine Product Introductionrecombinant, expressed in rice, suitable for cell culture, low endotoxin;It is a kind of recombinant human albumin (RHA) without animal origin. It is designed for cell culture applications and is a powerful medium supplement with superior performance to human albumin, bovine serum albumin and recombinant human albumin from other sources.It brings stable and consistent performance rather than variables related to hydrolysates and extracts. It is an ideal medium for Chinese hamster ovary (CHO), hybridoma, Vero, stem cell and primary cell culture medium.The recombinant variant is recommended for absorption, transport, metabolism and excretion (ADME) pharmacology; cell culture; drug delivery; and cell cryopreservation... Read More | Inquire | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months | Purity>97% SDS-PAGE.FunctionReceptor for interleukin-2 | Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： 100B, previously called S100 beta, belongs to the S100 family within the EF-hand superfamily of Ca2+ binding proteins. S100 proteins contain two EF-hand motifs that differ in affinity, separated by a hingePurity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： 100B, previously called S100 beta, belongs to the S100 family within the EF-hand superfamily of Ca2+ binding proteins. S100 proteins contain two EF-hand motifs that differ in affinity, separated by a hinge region with a hydrophobic cleft that is exposed upon Ca2+ binding. S100B is a 91 amino acid (aa) protein, after removal of the initial methionine, and is found as homodimers of 10.4 kDa monomers. Human S100B shares 99%, 98%, 100%, 99% and 97% aa sequence identity with mouse, rat, rabbit, equine and bovine S100B, respectively. Within the S100 family, human S100B shows the highest aa identity (59%) with S100A1. S100B is expressed primarily by astrocytes and oligodendrocytes in the central nervous system, and by Schwann cells in the peripheral nervous system. Ca2+-bound S100B interacts in vitro with at least 20 cytoplasmic proteins, including several structural molecules such as tubulin and GFAP. It can inhibit the phosphorylation of these kinase substrates and others such as tau and neuromodulin. Astrocytes can secrete S100B, which then acts in a cytokine-like manner. Nanomolar concentrations of S100B are secreted constitutively, promote proliferation, and are neurotrophic and anti-apoptotic. Blood levels of S100B reflect extracellular concentrations within the nervous system, and are elevated in Down’s syndrome, Alzheimer’s disease and Tourette’s syndrome, metabolic stress, acute brain injury and brain tumors. Micromolar concentrations of S100B can be destructive and pro-apoptotic; they induce the expression of iNOS, COX-2, IL-1, IL‑6 and TNF-alpha by microglia, astrocytes or neurons. Most extracellular actions of S100B can be mediated by RAGE (receptor for advanced glycation end products), which is also a receptor for other S100 proteins... Read More |