| Description | DescriptionLinear double-stranded lambda bacteriophage (cI857 Sam7) DNA, 48502 base pairs with a molecular weight of 31.5 106 Da. Isolated from a heat-inducible lysogenic E.coli W3110 strain. GeneBank/EMBL accession numbers NC_001416, M17233, M24325, V00636, X00906. Applications Activity DescriptionLinear double-stranded lambda bacteriophage (cI857 Sam7) DNA, 48502 base pairs with a molecular weight of 31.5 106 Da. Isolated from a heat-inducible lysogenic E.coli W3110 strain. GeneBank/EMBL accession numbers NC_001416, M17233, M24325, V00636, X00906. Applications Activity and specificity assays of restriction enzymes. Preparation of DNA molecular weight standards. Cloning.Storage Buffer 10 mM Tris-HCl (pH 7.6) and 1 mM EDTA.Source ：E. coli... Read More | Inquire | Inquire | Tankyrase-IN-2 (compound 5k) is a potent, selective, and orally active tankyrase inhibitor ( IC 50 s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively). Tankyrase-IN-2 has favorable physicochemical profile and pharmacokinetic properties modulating Wnt pathway activity in a Tankyrase-IN-2 (compound 5k) is a potent, selective, and orally active tankyrase inhibitor ( IC 50 s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively). Tankyrase-IN-2 has favorable physicochemical profile and pharmacokinetic properties modulating Wnt pathway activity in a colorectal xenograft modelIn VitroTankyrase-IN-2 (1-10000 nM; 24 hours) leads to a dose-dependent increase of tankyrase protein abundance with an EC 50 of 320 nM in DLD1 cells. This is in the same potency range as the value for axin2 increase (EC 50 =319 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:IC50: 10 nM (TNKS1), 7 nM (TNKS2), 710 nM (PARP1)... Read More | Inquire |