| Description | Hepases, derived from microorganisms, are polysaccharide lyases that cleave the a-1,4 glycosidic bond between N-acetylglucosamine (GlcNAc) and hexuronic acid (GlcUA/IdoUA) through a typical b-elimination mechanism. They generate an unsaturated double bond with specific absorption at 232 nm at the C4Hepases, derived from microorganisms, are polysaccharide lyases that cleave the a-1,4 glycosidic bond between N-acetylglucosamine (GlcNAc) and hexuronic acid (GlcUA/IdoUA) through a typical b-elimination mechanism. They generate an unsaturated double bond with specific absorption at 232 nm at the C4 and C5 positions of hexuronic acid, which facilitates the analysis and detection of enzymatic hydrolysis products. HEPases have been identified in Hep/HS degrading bacteria, such as Flavobacterium heparinum, Bacteroides thetaiotaomicron,Bacteroides stercoris,Sphingomonas, Bacillus, Pseudomonas aeruginosa[ Wait. HEPases can be divided into three categories based on substrate selectivity: HEPase I selectively degrades the high sulfation zone in Hep and HS; HEPase III selectively degrades the low sulfur acidification zone in HS and Hep; HEPase II can degrade both Hep and HS simultaneously. The above three types of HEPases belong to endonucleases, and recently a heparin exonuclease family (exoHEPases) has been discovered for the first time. HEPases, as an important tool enzyme, are widely used in the structural and functional research of Hep/HS, the production of low molecular weight heparin, quality testing and consistency evaluation of heparin drugs, etc. We can provide customers with various known types of HEPase enzyme preparations according to their needs, meeting their various requirements from analysis and detection to large-scale production.ApplicationHeparinase I and III Blend from Flavobacterium heparinum has been used in:the digestion of heparan sulfate from ovine vitreous;human embryonic kidney cells;glycosaminoglycans from arterial tissues;P0 retinae digestion... Read More | Inquire | Purity≥ 95% SDS-PAGE.Additional sequence informationMature chain.FunctionCould be a growth factor active in the process of wound healing. Acts as a mitogen in the lung. May act in a manner similar to FGF-7 | Purity>98% by SDS-PAGE and HPLC analyses.Additional sequence informationBelongs to the intercrine alpha (chemokine CxC) family.FunctionActs as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in Purity>98% by SDS-PAGE and HPLC analyses.Additional sequence informationBelongs to the intercrine alpha (chemokine CxC) family.FunctionActs as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.Post-translationalGlycosylated... Read More | The recombinant Protein A is a genetically engineering protein containing IgG-binding domains.Recombinant Protein A is ideal for purification of polyclonal or monoclonal IgG antibodies. Protein A binds to most human and mouse IgG subclasses (e.g., human IgG1, IgG2, IgG4; mouse IgG2, IgG2a, IgG2b,The recombinant Protein A is a genetically engineering protein containing IgG-binding domains.Recombinant Protein A is ideal for purification of polyclonal or monoclonal IgG antibodies. Protein A binds to most human and mouse IgG subclasses (e.g., human IgG1, IgG2, IgG4; mouse IgG2, IgG2a, IgG2b,IgG3). It also binds to cow, guinea pig, hamster, house, pig and rabbit total IgG form.Recombinant protein A can be coupled to solid separation medium (such as agarose) for monoclonaland polyclonal antibody purification. Recombinant protein A can be coupled to a variety of molecules (such as fluorescent molecules, enzyme markers, biotin, colloidal gold and radioactive markers). These coupled derivatives can be used in antibody test in the process of Western-blot, ELISA or immunohistochemical tests... Read More |