| Description | MW: 37,000****Azurocidin is highly glycosylated, which causes the protein to show a lower molecular weight by SDS-PAGE than that stated of 37kDa.The gene for azurocidin is located on the short arm of chromosome 19 and is in a cluster with the genes for proteinase 3 and elastase. All three proteins MW: 37,000****Azurocidin is highly glycosylated, which causes the protein to show a lower molecular weight by SDS-PAGE than that stated of 37kDa.The gene for azurocidin is located on the short arm of chromosome 19 and is in a cluster with the genes for proteinase 3 and elastase. All three proteins are serine protease homologues; azurocidin, however, lacks enzymatic activity. The importance of azurocidin is its role as a multifunctional inflammatory mediator. It has antimicrobial activity, binds endotoxin and is chemotactic for monocytes. Product Citation:Zimmer M, Medcalf RL, Fink TM, Mattman C, Lichter P, and Jenne DE. 1992. Proc. Natl. Acad. Sci. USA 89, 8215. Pereira HA. 1995. J Leukoc Biol. 57, 805.O'Flynn, J., K. O. Dixon, Faber Krol, M. R. Daha, and C. van Kooten. "Myeloperoxidase Directs Properdin-Mediated Complement Activation." Journal of Innate Immunity (2013).Brandt K, Grunler J, Brismar K, Wang JEffects of IGFBP-1 and IGFBP-2 and their fragments on migration and IGF-induced proliferation of human dermal fibroblasts.Growth Horm IGF Res. 2015 Feb;25(1):34-40. doi: 10.1016/j.ghir.2014.11.001. Epub 2014 Nov 8... Read More | Inquire | Inquire | Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining.Description:ER alpha (Estrogen receptor alpha; also Estradiol receptor and NR3A1) is a 65-70 kDa member of the NR3 subfamily, nuclear hormone receptor family of proteins. It is widely expressed, and serves as a strong Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining.Description:ER alpha (Estrogen receptor alpha; also Estradiol receptor and NR3A1) is a 65-70 kDa member of the NR3 subfamily, nuclear hormone receptor family of proteins. It is widely expressed, and serves as a strong activator of estrogen-responsive genes. ER alpha is normally quiescent and bound to heat-shock proteins and immunophilins. Following beta -estradiol binding, it becomes activated, either homodimerizes or heterodimerizes with ER beta, and binds to DNA with multiple coactivators. Human ER alpha is 595 amino acids (aa) in length. It contains a DNA binding region (aa 185-250), three NLSs (aa 256-260; 266-271; 299-303), a steroid-binding site (aa 351-543), a dimerization motif (aa 497-518), and an O-GlcNAc attachment around Thr575. Major phosphorylation sites exist at Tyr537, Ser167 and Ser118. Multiple splice forms exist. There is an 80 kDa isoform that shows a substitution (duplication) of aa 412-517 for Asp411, a second isoform with a deletion of aa 255-366, a third isoform with a deletion of aa 152-412, and a fourth isoform that shows a Thr substitution for aa 152-595. Human ER alpha is only 46% aa identical to human ER beta. Over aa 1-116, human ER alpha shares 85% aa identity with mouse ER alpha... Read More | Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue StainingDescription:ROR1 (Receptor tyrosine kinase-like orphan receptor 1), also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1), is a member of the ROR family within the receptor tyrosine kinases (RTK) superfamily. Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue StainingDescription:ROR1 (Receptor tyrosine kinase-like orphan receptor 1), also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1), is a member of the ROR family within the receptor tyrosine kinases (RTK) superfamily. Two ROR family members (ROR1 and ROR2) have been identified and are characterized by their intracellular tyrosine kinase domains, which are highly related to those of the Trk-family receptor tyrosine kinases, and by their extracellular Frizzled-like cysteine-rich domains and kringle domains, common to receptors of the Wnt family members. Human ROR1 is a type I transmembrane protein with 937 amino acids in length. It contains a 29 amino acid signal sequence, a 377 amino acid extracellular domain (ECD), a 21 amino acid transmembrane segment, and a 510 amino acid cytoplasmic region. Human ROR1 shares 97% and 58% amino acid sequence identity with mouse ROR1 and human ROR2, respectively. ROR1 has been shown to play crucial roles in developmental morphogenesis by acting as receptors or co-receptors to mediate Wnt5a-induced signaling. The bioactivity of ROR1 is measured by its ability to bind biotinylated recombinant mouse Wnt-5a in a functional ELISA... Read More |