| Description | Extinction Coefficient: 0.70 In normal plasma LRG1 has a concentration of 21-50 ug/ml. It is an acute phase protein with levels elevated in patients with bacterial infections; interestingly, during the inflammatory response, LRG1 levels are not correlated with CRP levels. LRG1 binds cytochrome c, anExtinction Coefficient: 0.70 In normal plasma LRG1 has a concentration of 21-50 ug/ml. It is an acute phase protein with levels elevated in patients with bacterial infections; interestingly, during the inflammatory response, LRG1 levels are not correlated with CRP levels. LRG1 binds cytochrome c, an initiator/amplifier of programmed cell death (apoptosis), and by binding cytochrome c, is thought to play a role in cell survival. LRG1 is a biomarker associated with several cancers, including non-small cell lung cancer, colorectal cancer, and pancreatic cancer. Recent studies have shown it is three-fold more abundant in ovarian cancer serum compared to non-cancer control serum. LRG1 levels are only moderately correlated with CA125 levels. Elevated levels of LRG1 in cerebral spinal fluid are being studied as markers for the early diagnosis of Parkinson's disease and progressive supranuclear palsy... Read More | Inquire | Inquire | Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining.Description:Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells,Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining.Description:Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity).Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation (By similarity).Fc-binding subunit that associates with FCER1G adapter to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapter with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation (By similarity).Mediates enhanced ADCC in response to afucosylated IgGs (By similarity)... Read More | Purity> 95 % by SDS-PAGE and HPLC analysesFunctionThis receptor has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen) |