| Description | Inter Alpha Inhibitor Proteins (IaIp)- include Inter Alpha Trypsin Inhibitor (IaI) and Pre Alpha Inhibitor (Pal), with molecular weights of 225 kDa and 125 kDa respectively. Together these proteins are present in plasma at a concentration of approximately 50 mg/100 ml. The inhibitory activity of theInter Alpha Inhibitor Proteins (IaIp)- include Inter Alpha Trypsin Inhibitor (IaI) and Pre Alpha Inhibitor (Pal), with molecular weights of 225 kDa and 125 kDa respectively. Together these proteins are present in plasma at a concentration of approximately 50 mg/100 ml. The inhibitory activity of the proteins is a function of bikunin, the common light chain of the IAIP.In acute inflammation, the lal acts as a negative acute-phase protein, whereas the Pal acts as a positive acute-phase protein. IaIp are being considered as biomarkers and biotherapies for metastatic disease, septic shock and complement system disorders.Activity: Shows inhibitory activity when tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate.Immunoblotting: Immunoreactive with anti-BikuninPrepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.For research use or for use in further manufacturing... Read More | Inquire | Inquire | Purity: >90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description: Major histocompatibility complex, class II, DR alpha (HLA-DRA) belongs to the MHC class II family. HLA-DRA binds peptides derived from antigens which access the endocytic route of antigen presenting cells (APC) Purity: >90%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description: Major histocompatibility complex, class II, DR alpha (HLA-DRA) belongs to the MHC class II family. HLA-DRA binds peptides derived from antigens which access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for identification by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mainly by degradation of proteins which access the endocytic route, where they are processed by lysosomal proteases and other hydrolases... Read More | Purity>95% SDS-PAGE.FunctionReceptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the Purity>95% SDS-PAGE.FunctionReceptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity... Read More |