| Description | C-Reactive Protein (CRP) is a homopentameric protein with a monomer size of ~24 kDa. It is a member of the pentraxin family, a family of proteins characterized by their calcium dependent ligand binding and unique ring-like structure. Like many other pentraxins, CRP is highly upregulated in the acuteC-Reactive Protein (CRP) is a homopentameric protein with a monomer size of ~24 kDa. It is a member of the pentraxin family, a family of proteins characterized by their calcium dependent ligand binding and unique ring-like structure. Like many other pentraxins, CRP is highly upregulated in the acute-phase response to bodily insults such as tissue injuries, infections and general inflammation. In normal, healthy individuals the concentration of CRP in blood is ~5 mg/ml. This number rises 5-10 fold in response to infection or other causes of inflammation. In severe cases, CRP levels can rise above 200 mg/L. CRP can be used as a biomarker for general inflammation or more specific issues such as certain cancers, diabetes, hypertension, cardiovascular disease (CVD) or Rheumatoid Arthritis (RA). On a cellular/molecular level, CRP activates the complement system of the immune response by binding to surface molecules on dead/dying cells or foreign/invading bacteria. Laboratories and companies investigating the diseases mentioned, complement system induction or the acute phase would find our CRP a useful reagent in their studies. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. Aladdin products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only... Read More | Inquire | Arachis hypogaea lectin or Peanut Agglutinin (PNA) is isolated from peanuts and purified by affinity chromatography. The lectin has a molecular weight of 110 kDa and consists of four identical subunits of approximately 27 kDa each. PNA is a carbohydrate-free protein that displays specificity towardsArachis hypogaea lectin or Peanut Agglutinin (PNA) is isolated from peanuts and purified by affinity chromatography. The lectin has a molecular weight of 110 kDa and consists of four identical subunits of approximately 27 kDa each. PNA is a carbohydrate-free protein that displays specificity towards ?-D-Gal(1-3)-D-galNAc. It has potent anti-T activity and can be used to distinguish between human lymphocyte subsets. PNA has been used in tumour tissue determination for transitional mucosa malignancies. The lectin also agglutinates neuraminidase-treated human erythrocytes at < 0.1 µg/ml after trypsin treatment of cells and its activity is inhibited by lactose and galactose. PNA lectin is provided as a white to light yellow lyophilized powder from a buffer containing 10 mM NH4HCO3. The purity is determined by SDS-PAGE, which generates one band at 25-27 kDa.● Ultrapure quality ● Strong anti-T activity ● Sugar specificity: ?-D-Gal-(1-3)-D-GalNAc ● Agglutinates rabbit erythrocytes at < 0.1 µg/ml after trypsin treatment of the cells ● Lyophilized powderProbe in histochemistry and immuno-histochemistry;Human erythrocyte/lymphocyte studies... Read More | IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC 50 of 4 µM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disordersIn VitroIRAK-4 IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC 50 of 4 µM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disordersIn VitroIRAK-4 protein kinase inhibitor 2 (compound 1) also inhibits IRAK-1, with an IC 50 of <10 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IRAK4 4 µM (IC 50 )... Read More | Inquire |