| Description | KIR2DS1 Human Pre-designed siRNA Set A contains three designed siRNAs for KIR2DS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control. Components KIR2DS1 siRNA-1: 5 nmol (HPLC) KIR2DS1 siRNA-2: 5 nmol (HPLC) KIR2DS1 siRNA-3: 5 nmol (HPLC) siRNA KIR2DS1 Human Pre-designed siRNA Set A contains three designed siRNAs for KIR2DS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control. Components KIR2DS1 siRNA-1: 5 nmol (HPLC) KIR2DS1 siRNA-2: 5 nmol (HPLC) KIR2DS1 siRNA-3: 5 nmol (HPLC) siRNA Negative Control: 5 nmol (HPLC) FAM-labeled siRNA Negative Control: 5 nmol (HPLC) GAPDH siRNA Positive Control:5 nmol (HPLC)... Read More | Inquire | Protein:BSA-Free | Tankyrase-IN-2 (compound 5k) is a potent, selective, and orally active tankyrase inhibitor ( IC 50 s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively). Tankyrase-IN-2 has favorable physicochemical profile and pharmacokinetic properties modulating Wnt pathway activity in a Tankyrase-IN-2 (compound 5k) is a potent, selective, and orally active tankyrase inhibitor ( IC 50 s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively). Tankyrase-IN-2 has favorable physicochemical profile and pharmacokinetic properties modulating Wnt pathway activity in a colorectal xenograft modelIn VitroTankyrase-IN-2 (1-10000 nM; 24 hours) leads to a dose-dependent increase of tankyrase protein abundance with an EC 50 of 320 nM in DLD1 cells. This is in the same potency range as the value for axin2 increase (EC 50 =319 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:IC50: 10 nM (TNKS1), 7 nM (TNKS2), 710 nM (PARP1)... Read More | Biochemical Test:Electrophoresis (purity > 80%) |