Quadrupole mass spectrometers are perhaps the simplest of mass spec instruments. Functioning effectively like a radio, the quadrupole MS – so-named because of its four charged rods, which run parallel to the flight paths of the ions it measures – filter ions by mass-to-charge ratio (m/z) by altering the voltages in the rods. Quadrupole mass spectrometers are available in a variety of formats, including a single quadrupole mass spectrometer, a triple quadrupole MS (three quadrupoles arranged in tandem), and a Q-TOF (a triple quad variant in which the third quadrupole is replaced with a time-of-flight mass analyzer).
Quadrupole mass analyzers are often used for targeted, quantitative applications and can be used either to measure one or a few given ions in a mixture, or to scan across a range of m/z values. Depending on the configuration, they can facilitate both MS and MS/MS applications. For instance, in a triple-quadrupole mass spectrometer, you can select ions for analysis in the first quadrupole, fragment them by collision with a gas in the second quadrupole, and analyze the resulting fragmentation ions in the third quadrupole.
Find, compare, and request a quote for quadrupole mass spectrometers across leading suppliers at Labcompare; including access to product citations, related published figures, and first-hand reviews from our scientific community.
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Company | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific |
Item | Orbitrap Astral Mass Spectrometer | Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer | Thermo Scientific™ Q Exactive™ Plus Hybrid Orbitrap™ Mass Spectrometer | Thermo Scientific™ TSQ™ 9610 Triple Quadrupole GC-MS/MS System | Thermo Scientific™Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ LC-MS/MS Mass Spectrometer |
Citations | | | | | |
Catalog Number | Orbitrap Astral Mass Spectrometer | IQLAAEGAAPFADBMBHQ | IQLAAEGAAPFALGMBDK | IQLAAAGABNFARPMBNB | IQLAAEGAAPFALGMBDK |
Price | | | | | |
Ionization Method(s) | Adjustable heated electrospray ionization (HESI) probe | HESI | Inquire | Varies by model, AEI, EI, CI | APCI, H-ESI |
Mass Analyzer | Orbitrap mass analyzer ranging from 7,500 to 480,000 resolution at m/z 200
Astral mass analyzer is operated at a single resolution setting of 80,000 at m/z 524 | Orbitrap | Hybrid Quadrupole-Orbitrap™ | Triple quadrupole | Hybrid Quadrupole / Orbitrap |
Scanning Speed | Up to 200 Hz | Inquire | Up to 12 Hz | Inquire | Up to 12 Hz |
Mass Range | Maximum Astral mass analyzer resolution up to 80,000 FWHM at m/z 524
Maximum Orbitrap mass analyzer resolution of up to 480,000 FWHM at m/z 200 | m/z 50–2,000
m/z 200–4,000
up to m/z 6,000 without precursor ion selection (OTMS only) | 50 to 6,000 m/z | Inquire | 50 to 6,000 m/z |
Description | Inquire | Excel at the most challenging of applications, including low level PTM analysis, multiplexed relative quantitation using isobaric tags, intact protein characterization, as well as MSn analysis of small molecules with the new Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer. ThisExcel at the most challenging of applications, including low level PTM analysis, multiplexed relative quantitation using isobaric tags, intact protein characterization, as well as MSn analysis of small molecules with the new Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer. This system incorporates the brightest ion source, a segmented quadrupole mass filter with improved selectivity and ion transmission, Advanced Vacuum Technology for improved ion transmission to the Thermo Scientific™ Orbitrap™ mass analyzer, and ETD HD, a higher-capacity ETD fragmentation. Latest innovations include the Advanced Peak Determination (APD) algorithm for improved data-dependent experiments and two new hardware options: UVPD, a new fragmentation technique achieved with a 213 nm UV laser and 1M, which provides 1,000,000 FWHM ultra-high resolution for improved structural elucidation and quantitation of isobaric compounds.... Read More | Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased performance and new options that enhance applications from confident DMPK qual/quan screening studies to characterization of intact monoclonal antibodies.... Read More | The TSQ 9610 GC-MS/MS system is designed to revolutionize laboratory productivity by delivering unprecedented levels of performance and reduce cost per sample for the high-throughput environment. | Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased performance and new options that enhance applications from confident DMPK qual/quan screening studies to characterization of intact monoclonal antibodies.
Features: - Advanced Quadrupole technology featuring Thermo Fisher segmented HyperQuad
- Resolving power up to 280,000
- Maximum scan speed 12 Hz
- Spectral multiplexing for enhanced duty cycle
- RF-Lens ion source for increased sensitivity
- Advanced Active Beam Guide intelligent ion beam management for high flux ion sources
- Intact Protein Mode option for characterizing intact proteins with ease
- Enhanced Resolution Option maximizing resolution at 280,000
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