Quadrupole mass spectrometers are perhaps the simplest of mass spec instruments. Functioning effectively like a radio, the quadrupole MS – so-named because of its four charged rods, which run parallel to the flight paths of the ions it measures – filter ions by mass-to-charge ratio (m/z) by altering the voltages in the rods. Quadrupole mass spectrometers are available in a variety of formats, including a single quadrupole mass spectrometer, a triple quadrupole MS (three quadrupoles arranged in tandem), and a Q-TOF (a triple quad variant in which the third quadrupole is replaced with a time-of-flight mass analyzer).
Quadrupole mass analyzers are often used for targeted, quantitative applications and can be used either to measure one or a few given ions in a mixture, or to scan across a range of m/z values. Depending on the configuration, they can facilitate both MS and MS/MS applications. For instance, in a triple-quadrupole mass spectrometer, you can select ions for analysis in the first quadrupole, fragment them by collision with a gas in the second quadrupole, and analyze the resulting fragmentation ions in the third quadrupole.
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Company | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific |
Item | Thermo Scientific™ Q Exactive™ Plus Hybrid Orbitrap™ Mass Spectrometer | Orbitrap Astral Mass Spectrometer | Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ Mass Spectrometer | Thermo Scientific™ Exactive™ Plus EMR Orbitrap™ LC-MS System | Thermo Scientific™Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ LC-MS/MS Mass Spectrometer |
Citations | | | | | |
Catalog Number | IQLAAEGAAPFALGMBDK | Orbitrap Astral Mass Spectrometer | IQLAAEGAAPFALGMAZR | IQLAAEGAAPFALGMBDL | IQLAAEGAAPFALGMBDK |
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Ionization Method(s) | Inquire | Adjustable heated electrospray ionization (HESI) probe | Inquire | APCI, H-ESI | APCI, H-ESI |
Mass Analyzer | Hybrid Quadrupole-Orbitrap™ | Orbitrap mass analyzer ranging from 7,500 to 480,000 resolution at m/z 200
Astral mass analyzer is operated at a single resolution setting of 80,000 at m/z 524 | UHMR Hybrid Quadrupole-Orbitrap™ | Orbitrap | Hybrid Quadrupole / Orbitrap |
Scanning Speed | Up to 12 Hz | Up to 200 Hz | up to 12 Hz at resolution setting of 12,500 at m/z 400 | Up to 12 Hz | Up to 12 Hz |
Mass Range | 50 to 6,000 m/z | Maximum Astral mass analyzer resolution up to 80,000 FWHM at m/z 524
Maximum Orbitrap mass analyzer resolution of up to 480,000 FWHM at m/z 200 | 350 to 80,000 m/z | 350 to 20,000 m/z | 50 to 6,000 m/z |
Description | Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased performance and new options that enhance applications from confident DMPK qual/quan screening studies to characterization of intact monoclonal antibodies.... Read More | Inquire | The Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ mass spectrometer is the first to provide the unique combination of unprecedented ultra-high mass range resolution, highest sensitivity, and MS2 and pseudo-MS3 capabilities needed to go beyond what’s possible with today’s native MS The Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ mass spectrometer is the first to provide the unique combination of unprecedented ultra-high mass range resolution, highest sensitivity, and MS2 and pseudo-MS3 capabilities needed to go beyond what’s possible with today’s native MS experiments.... Read More | While analysis of denatured proteins may be the most common LC/MS protein analysis, many biopharmaceutical and biological research applications require analysis of proteins in their native (intact) state. The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines unsurpassed high-While analysis of denatured proteins may be the most common LC/MS protein analysis, many biopharmaceutical and biological research applications require analysis of proteins in their native (intact) state. The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines unsurpassed high-resolution accurate-mass Thermo Scientific™ Orbitrap™ analysis with an extended mass range (EMR) option to create an outstanding tool for investigating the structure, topology, and architecture of native-like tertiary and quaternary protein structures.... Read More | Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased performance and new options that enhance applications from confident DMPK qual/quan screening studies to characterization of intact monoclonal antibodies.
Features: - Advanced Quadrupole technology featuring Thermo Fisher segmented HyperQuad
- Resolving power up to 280,000
- Maximum scan speed 12 Hz
- Spectral multiplexing for enhanced duty cycle
- RF-Lens ion source for increased sensitivity
- Advanced Active Beam Guide intelligent ion beam management for high flux ion sources
- Intact Protein Mode option for characterizing intact proteins with ease
- Enhanced Resolution Option maximizing resolution at 280,000
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