Quadrupole mass spectrometers are perhaps the simplest of mass spec instruments. Functioning effectively like a radio, the quadrupole MS – so-named because of its four charged rods, which run parallel to the flight paths of the ions it measures – filter ions by mass-to-charge ratio (m/z) by altering the voltages in the rods. Quadrupole mass spectrometers are available in a variety of formats, including a single quadrupole mass spectrometer, a triple quadrupole MS (three quadrupoles arranged in tandem), and a Q-TOF (a triple quad variant in which the third quadrupole is replaced with a time-of-flight mass analyzer).
Quadrupole mass analyzers are often used for targeted, quantitative applications and can be used either to measure one or a few given ions in a mixture, or to scan across a range of m/z values. Depending on the configuration, they can facilitate both MS and MS/MS applications. For instance, in a triple-quadrupole mass spectrometer, you can select ions for analysis in the first quadrupole, fragment them by collision with a gas in the second quadrupole, and analyze the resulting fragmentation ions in the third quadrupole.
Find, compare, and request a quote for quadrupole mass spectrometers across leading suppliers at Labcompare; including access to product citations, related published figures, and first-hand reviews from our scientific community.
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Company | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific |
Item | Thermo Scientific™ ISQ™ EM Single Quadrupole Mass Spectrometer | Orbitrap Astral Mass Spectrometer | Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ Mass Spectrometer | Thermo Scientific™ Exactive™ Plus EMR Orbitrap™ LC-MS System | Thermo Scientific™ TSQ™ 9610 Triple Quadrupole GC-MS/MS System |
Citations | | | | | |
Catalog Number | IQLAAAGADIFZZZMZZZ | Orbitrap Astral Mass Spectrometer | IQLAAEGAAPFALGMAZR | IQLAAEGAAPFALGMBDL | IQLAAAGABNFARPMBNB |
Price | | | | | |
Ionization Method(s) | Atmospheric pressure ionization (API) source with interchangeable HESI and APCI probes | Adjustable heated electrospray ionization (HESI) probe | Inquire | APCI, H-ESI | Varies by model, AEI, EI, CI |
Mass Analyzer | Single quadrupole | Orbitrap mass analyzer ranging from 7,500 to 480,000 resolution at m/z 200
Astral mass analyzer is operated at a single resolution setting of 80,000 at m/z 524 | UHMR Hybrid Quadrupole-Orbitrap™ | Orbitrap | Triple quadrupole |
Scanning Speed | Up to 20,000 Da/sec. | Up to 200 Hz | up to 12 Hz at resolution setting of 12,500 at m/z 400 | Up to 12 Hz | Inquire |
Mass Range | 10 to 2000 m/z with Unit Mass Resolution | Maximum Astral mass analyzer resolution up to 80,000 FWHM at m/z 524
Maximum Orbitrap mass analyzer resolution of up to 480,000 FWHM at m/z 200 | 350 to 80,000 m/z | 350 to 20,000 m/z | Inquire |
Description | Adding mass spectrometry (MS) to your liquid chromatography (LC) analyses gives you access to the valuable data that only MS can provide. The new, easy-to-use ISQ™ EM Single Quadrupole Mass Spectrometer seamlessly integrates with LC systems for reliable, robust, and easy LC-MS routine analysis with Adding mass spectrometry (MS) to your liquid chromatography (LC) analyses gives you access to the valuable data that only MS can provide. The new, easy-to-use ISQ™ EM Single Quadrupole Mass Spectrometer seamlessly integrates with LC systems for reliable, robust, and easy LC-MS routine analysis with an extended mass range for more flexibility. Detect and quantify a variety of analytes by choosing to use either heated electrospray ionization (HESI) or atmospheric pressure chemical ionization (APCI). Integrated software allows both novices and experts to quickly master MS to gain more insights from every sample.... Read More | Inquire | The Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ mass spectrometer is the first to provide the unique combination of unprecedented ultra-high mass range resolution, highest sensitivity, and MS2 and pseudo-MS3 capabilities needed to go beyond what’s possible with today’s native MS The Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ mass spectrometer is the first to provide the unique combination of unprecedented ultra-high mass range resolution, highest sensitivity, and MS2 and pseudo-MS3 capabilities needed to go beyond what’s possible with today’s native MS experiments.... Read More | While analysis of denatured proteins may be the most common LC/MS protein analysis, many biopharmaceutical and biological research applications require analysis of proteins in their native (intact) state. The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines unsurpassed high-While analysis of denatured proteins may be the most common LC/MS protein analysis, many biopharmaceutical and biological research applications require analysis of proteins in their native (intact) state. The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines unsurpassed high-resolution accurate-mass Thermo Scientific™ Orbitrap™ analysis with an extended mass range (EMR) option to create an outstanding tool for investigating the structure, topology, and architecture of native-like tertiary and quaternary protein structures.... Read More | The TSQ 9610 GC-MS/MS system is designed to revolutionize laboratory productivity by delivering unprecedented levels of performance and reduce cost per sample for the high-throughput environment. |
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