Quadrupole mass spectrometers are perhaps the simplest of mass spec instruments. Functioning effectively like a radio, the quadrupole MS – so-named because of its four charged rods, which run parallel to the flight paths of the ions it measures – filter ions by mass-to-charge ratio (m/z) by altering the voltages in the rods. Quadrupole mass spectrometers are available in a variety of formats, including a single quadrupole mass spectrometer, a triple quadrupole MS (three quadrupoles arranged in tandem), and a Q-TOF (a triple quad variant in which the third quadrupole is replaced with a time-of-flight mass analyzer).
Quadrupole mass analyzers are often used for targeted, quantitative applications and can be used either to measure one or a few given ions in a mixture, or to scan across a range of m/z values. Depending on the configuration, they can facilitate both MS and MS/MS applications. For instance, in a triple-quadrupole mass spectrometer, you can select ions for analysis in the first quadrupole, fragment them by collision with a gas in the second quadrupole, and analyze the resulting fragmentation ions in the third quadrupole.
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Company | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific |
Item | TriPlus™ RSH µSPE autosampler | Orbitrap Astral Mass Spectrometer | Thermo Scientific™ Exactive™ Plus EMR Orbitrap™ LC-MS System | Thermo Scientific™ ISQ™ EM Single Quadrupole Mass Spectrometer | TSQ Altis™ MD Mass Spectrometer |
Catalog Number | IQLAAEGAAUFAMKMBMF | Orbitrap Astral Mass Spectrometer | IQLAAEGAAPFALGMBDL | IQLAAAGADIFZZZMZZZ | IQLAAEGAAXFAQSMBLC |
Price | | | | | |
Ionization Method(s) | ESI | Adjustable heated electrospray ionization (HESI) probe | APCI, H-ESI | Atmospheric pressure ionization (API) source with interchangeable HESI and APCI probes | Inquire |
Mass Analyzer | Hybrid Quadrupole / Orbitrap | Orbitrap mass analyzer ranging from 7,500 to 480,000 resolution at m/z 200
Astral mass analyzer is operated at a single resolution setting of 80,000 at m/z 524 | Orbitrap | Single quadrupole | Triple quadrupole |
Scanning Speed | Inquire | Up to 200 Hz | Up to 12 Hz | Up to 20,000 Da/sec. | Inquire |
Mass Range | Inquire | Maximum Astral mass analyzer resolution up to 80,000 FWHM at m/z 524
Maximum Orbitrap mass analyzer resolution of up to 480,000 FWHM at m/z 200 | 350 to 20,000 m/z | 10 to 2000 m/z with Unit Mass Resolution | 5 to 3000 m/z |
Description | The Thermo Scientific™ TriPlus™ RSH µSPE autosampler offers the automation of complex and time-consuming sample preparation workflows fully integrated with LC-MS analysis for simplicity, such as calibration dilutions, internal standard addition, and µSPE clean-up. | Inquire | While analysis of denatured proteins may be the most common LC/MS protein analysis, many biopharmaceutical and biological research applications require analysis of proteins in their native (intact) state. The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines unsurpassed high-While analysis of denatured proteins may be the most common LC/MS protein analysis, many biopharmaceutical and biological research applications require analysis of proteins in their native (intact) state. The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines unsurpassed high-resolution accurate-mass Thermo Scientific™ Orbitrap™ analysis with an extended mass range (EMR) option to create an outstanding tool for investigating the structure, topology, and architecture of native-like tertiary and quaternary protein structures.... Read More | Adding mass spectrometry (MS) to your liquid chromatography (LC) analyses gives you access to the valuable data that only MS can provide. The new, easy-to-use ISQ™ EM Single Quadrupole Mass Spectrometer seamlessly integrates with LC systems for reliable, robust, and easy LC-MS routine analysis with Adding mass spectrometry (MS) to your liquid chromatography (LC) analyses gives you access to the valuable data that only MS can provide. The new, easy-to-use ISQ™ EM Single Quadrupole Mass Spectrometer seamlessly integrates with LC systems for reliable, robust, and easy LC-MS routine analysis with an extended mass range for more flexibility. Detect and quantify a variety of analytes by choosing to use either heated electrospray ionization (HESI) or atmospheric pressure chemical ionization (APCI). Integrated software allows both novices and experts to quickly master MS to gain more insights from every sample.... Read More | Achieve the sensitivity to perform routine quantitative analyses with remarkable speed and robustness. The Thermo Scientific™ TSQ Quantis™ MD Series mass spectrometer can be used by clinical diagnostic laboratories to meet their routine requirements for laboratory developed tests (LDTs). With ActiveAchieve the sensitivity to perform routine quantitative analyses with remarkable speed and robustness. The Thermo Scientific™ TSQ Quantis™ MD Series mass spectrometer can be used by clinical diagnostic laboratories to meet their routine requirements for laboratory developed tests (LDTs). With Active Ion Management (AIM+) technology,the TSQ Quantis MD Series delivers confident quantitation for routine analyses of human specimens.... Read More |
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