Quadrupole mass spectrometers are perhaps the simplest of mass spec instruments. Functioning effectively like a radio, the quadrupole MS – so-named because of its four charged rods, which run parallel to the flight paths of the ions it measures – filter ions by mass-to-charge ratio (m/z) by altering the voltages in the rods. Quadrupole mass spectrometers are available in a variety of formats, including a single quadrupole mass spectrometer, a triple quadrupole MS (three quadrupoles arranged in tandem), and a Q-TOF (a triple quad variant in which the third quadrupole is replaced with a time-of-flight mass analyzer).
Quadrupole mass analyzers are often used for targeted, quantitative applications and can be used either to measure one or a few given ions in a mixture, or to scan across a range of m/z values. Depending on the configuration, they can facilitate both MS and MS/MS applications. For instance, in a triple-quadrupole mass spectrometer, you can select ions for analysis in the first quadrupole, fragment them by collision with a gas in the second quadrupole, and analyze the resulting fragmentation ions in the third quadrupole.
Find, compare, and request a quote for quadrupole mass spectrometers across leading suppliers at Labcompare; including access to product citations, related published figures, and first-hand reviews from our scientific community.
| | | | | |
Company | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific |
Item | Thermo Scientific™ Exactive™ Plus EMR Orbitrap™ LC-MS System | Orbitrap Astral Mass Spectrometer | Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ Mass Spectrometer | Thermo Scientific™ ISQ™ 7610 Single Quadrupole GC-MS System | Thermo Scientific™ TSQ™ 9610 Triple Quadrupole GC-MS/MS System |
Citations | | | | | |
Catalog Number | IQLAAEGAAPFALGMBDL | Orbitrap Astral Mass Spectrometer | IQLAAEGAAPFALGMAZR | IQLAAAGAAJFALOMBNA | IQLAAAGABNFARPMBNB |
Price | | | | | |
Ionization Method(s) | APCI, H-ESI | Adjustable heated electrospray ionization (HESI) probe | Inquire | EI, FS, SIM, FS/SIM, CI, PCI, NCI, depending on model | Varies by model, AEI, EI, CI |
Mass Analyzer | Orbitrap | Orbitrap mass analyzer ranging from 7,500 to 480,000 resolution at m/z 200
Astral mass analyzer is operated at a single resolution setting of 80,000 at m/z 524 | UHMR Hybrid Quadrupole-Orbitrap™ | Triple off-axis Thermo Scientific™ DynaMax™ XTEND XR detection system, with off-axis 10 kV dynode, discrete dynode electron multiplier and electrometer, linear from 0 to 110 µA | Triple quadrupole |
Scanning Speed | Up to 12 Hz | Up to 200 Hz | up to 12 Hz at resolution setting of 12,500 at m/z 400 | Inquire | Inquire |
Mass Range | 350 to 20,000 m/z | Maximum Astral mass analyzer resolution up to 80,000 FWHM at m/z 524
Maximum Orbitrap mass analyzer resolution of up to 480,000 FWHM at m/z 200 | 350 to 80,000 m/z | 1.2–1100 u with Unit Mass Resolution | Inquire |
Description | While analysis of denatured proteins may be the most common LC/MS protein analysis, many biopharmaceutical and biological research applications require analysis of proteins in their native (intact) state. The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines unsurpassed high-While analysis of denatured proteins may be the most common LC/MS protein analysis, many biopharmaceutical and biological research applications require analysis of proteins in their native (intact) state. The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines unsurpassed high-resolution accurate-mass Thermo Scientific™ Orbitrap™ analysis with an extended mass range (EMR) option to create an outstanding tool for investigating the structure, topology, and architecture of native-like tertiary and quaternary protein structures.... Read More | Inquire | The Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ mass spectrometer is the first to provide the unique combination of unprecedented ultra-high mass range resolution, highest sensitivity, and MS2 and pseudo-MS3 capabilities needed to go beyond what’s possible with today’s native MS The Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ mass spectrometer is the first to provide the unique combination of unprecedented ultra-high mass range resolution, highest sensitivity, and MS2 and pseudo-MS3 capabilities needed to go beyond what’s possible with today’s native MS experiments.... Read More | Developed to enhance user experience in their workflows, the ISQ 7610 GC-MS system is streamlined to ensure great data consistency over time while offering automated instrument control tools. | The TSQ 9610 GC-MS/MS system is designed to revolutionize laboratory productivity by delivering unprecedented levels of performance and reduce cost per sample for the high-throughput environment. |
Get Quote | | | | | |