MALDI TOF mass spectrometers (matrix-assisted laser desorption/ionization/time-of-flight) are amongst the most popular mass spec instruments in biology. They combine two technologies, the “soft” MALDI ionization source and the TOF mass analyzer. The latter measures an ion’s mass-to-charge ratio (m/z) by measuring the time it takes to reach a detector. The former volatilizes and ionizes those molecules using a laser, a target, and an organic compound called a matrix. In MALDI, a sample (for instance, a collection of tryptic peptides) is mixed with matrix, spotted and dried (crystallized) on the surface of a metal target plate. Upon irradiation with laser light, the matrix absorbs the energy and converts it to heat, which then causes the sample to ionize and explode off the plate into the mass analyzer. MALDI TOF mass spectrometers come in two basic flavors, MALDI TOF MS and MALDI TOF/TOF MS; the latter enables tandem MS (MS/MS) studies.
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| Company | Shimadzu | Shimadzu | Shimadzu |
| Item | MALDI-8030 EasyCare Benchtop Linear Dual Polarity MALDI-TOF Mass Spectrometer | MALDImini-1 Compact MALDI Digital Ion Trap Mass Spectrometer | OmegaTOF Benchtop High Mass MALDI-TOF Mass Spectrometer |
| Catalog Number | MALDI-8030 | MALDImini-1 | OmegaTOF |
| Price | | | |
| Ionization Method(s) | MALDI | MALDI ion source | MALDI |
| Mass Analyzer | TOF | Digital Ion Trap (DIT) | Time-of-Flight |
| Resolution | >5000 FWHM – ACTH 18-39 (m/z 2465) | Inquire | >5000 FWHM – ACTH 18-39 (m/z 2465) |
| Mass Range | m/z 1 - 500,000 | Inquire | m/z 1,000–1,500,000Da |
| Description | The MALDI-8030 is a dual-polarity, benchtop linear MALDI-TOF mass spectrometer that delivers outstanding performance in a compact footprint, making it an ideal choice for today’s increasingly demanding laboratories.
The dual-polarity ion source of the MALDI-8030 allows the flexibility to analyze The MALDI-8030 is a dual-polarity, benchtop linear MALDI-TOF mass spectrometer that delivers outstanding performance in a compact footprint, making it an ideal choice for today’s increasingly demanding laboratories.
The dual-polarity ion source of the MALDI-8030 allows the flexibility to analyze a wide range of samples including proteins, peptides, oligonucleotides, lipids, glycans, polymers and small molecules. Its enhanced sample throughput, ease-of-use, low maintenance and small footprint make it ideal for all laboratories. Moreover, its quiet operation at <55 dB expands use beyond the conventional laboratory setting.
Key features include:
- Dual mode (positive/negative ion) MALDI-TOF; supports MS imaging at a benchtop scale
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200 Hz solid-state laser, 355 nm, for class-leading two billion shots per lifetime
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Load-lock chamber for fast sample introduction
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UV laser-based source cleaning (patented) – enables seamless self-cleaning of the ion optics, without breaking vacuum and requiring the removal of the ion optics
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Patented WideBore™ ion optics technology – significantly reduces contamination from the desorbed MALDI sample
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Easy routine maintenance of the ion optics
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Quiet operation (<55 dB)
In addition, the integrated barcode reader, when used with FlexiMass™-DS slides, is compatible with AuraSolution™ and SampleStation™ automated analysis software and can provide seamless tracking to reduce misidentification errors.
Tailored MALDI Solutions acquisition software features data security for regulatory compliance facilitated with password-controlled user login, encrypted data and user traceability.... Read More | Inquire | The OmegaTOF system couples Shimadzu’s benchtop MALDI-TOF instrument platform (MALDI-8020) with established technology for high mass detection from CovalX Instruments Inc. The result is a user-friendly, compact platform that extends benchtop MALDI-TOF analysis to a mass range of 1.5 MegaDalton.
TheThe OmegaTOF system couples Shimadzu’s benchtop MALDI-TOF instrument platform (MALDI-8020) with established technology for high mass detection from CovalX Instruments Inc. The result is a user-friendly, compact platform that extends benchtop MALDI-TOF analysis to a mass range of 1.5 MegaDalton.
The high mass detection capabilities of the OmegaTOF allow the highest sensitivity for analyzing large biomolecules, protein interactions, peptides, oligonucleotides and polymers. This allows access to a full range of applications already developed and optimized by CovalX technologies, most notably characterizing monoclonal antibodies, such as IgG, IgA and IgM. Crosslinking chemistries developed by CovalX enable the OmegaTOF to measure intact protein interactions directly, providing insight into protein aggregation, mAb:antigen interactions, protein complex stoichiometry or ligand association/dissociation measurements.
The OmegaTOF offers: - 200 Hz solid-state 355 nm laser featuring a class-leading two billion shots per lifetime
- Fast sample introduction using a load-lock chamber and quick sample stage movement
- Integrated barcode reader
- Patented TrueClean™ source cleaning
WideBore™ ion optics technologies that significantly reduce contamination from desorbed MALDI samples - Ease-of-use
- Low maintenance
- Small footprint
- Quiet operation at <55 dB
OmegaTOF data can be directly imported into the latest versions of CovalX ComplexTracker software for protein interaction analysis. Tailored MALDI Solutions acquisition software features data security for regulatory compliance facilitated with password-controlled user login, encrypted data, and user traceability. ... Read More |
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