Maldi TOF Mass Spectrometer (MALDI TOF MS)

An affordable, robust option for laboratories requiring routine manual or automated analysis of a wide variety of sample classes, the AXIMA Assurance provides high-quality, rapid MALDI mass spectra and an array of software tools for data processing and reporting. Incorporating a variable repetition

An affordable, robust option for laboratories requiring routine manual or automated analysis of a wide variety of sample classes, the AXIMA Assurance provides high-quality, rapid MALDI mass spectra and an array of software tools for data processing and reporting. Incorporating a variable repetition rate 50Hz N2 laser, it is ideally suited for high-throughput QA/QC analysis of oligonucleotide/primers, synthetic peptides/proteins, polymers, and other small molecules.

Features:

High Sensitivity/Resolution:
A variable repetition rate 50 Hz N2 laser and advanced ion optics for enhanced ion transmission enable users to meet all sample throughput requirements. Pulsed extraction of ions from the MALDI source improves resolution, and enhanced calibration algorithms with easy-to-use software provide more accurate data.

Positive and Negative Ion Modes Included as Standard:
Allows greater flexibility and extends the compound categories that may be analyzed.

Patented Beam Blanker:
Removes unwanted low mass ions and prevents detector saturation.

Unparalleled Flexibility:
A variety of sample target formats, including standard microtiter plate format 96 or 384 well targets, can be used. In addition, Fleximass™ microscope slides (plain or 48 well targets) and a wide variety of adaptors for unconventional sample layouts are available.

Like all AXIMA MALDI-TOF systems, the AXIMA Assurance can be fully integrated with robotic sample preparation devices, including the AccuSpot MALDI plate spotter and CHIP chemical printer, to create application-specific platforms. Integration with the CHIP creates a powerful platform for tissue imaging, while using an AXIMA instrument with a Prominence GPC system and AccuSpot results in a fully automated platform for polymer analysis that delivers quick, detailed analysis of ultra-trace substances.

The AXIMA Performance is one of the most powerful tools in mass spectrometry, delivering information-rich spectra with greater sensitivity and higher confidence in identification. Extremely versatile, this MALDI TOF-TOF mass spectrometer utilizes state-of-the-art high energy MS/MS, delivers

The AXIMA Performance is one of the most powerful tools in mass spectrometry, delivering information-rich spectra with greater sensitivity and higher confidence in identification. Extremely versatile, this MALDI TOF-TOF mass spectrometer utilizes state-of-the-art high energy MS/MS, delivers unparalleled flexibility in an ergonomic, robust and reliable research-grade system, and provides the pinnacle of performance for high-energy MS/MS interrogation of proteomics, biological and organic samples.

Features:

Highest Energy Collisions
A CID with a laboratory frame collisional energy of 20keV delivers true high-energy MS/MS and, together with the newly redesigned curved field reflectron, produces well-balanced, information-rich MS/MS data. The novel additional LMZ scan allows focus of the analysis to be directed around the low mass region of the MS/MS spectrum.

Revolutionary Gating Technology
Allows optimal isolation of precursor ions with market-leading optimal precursor ion selection (>400 resolution FWHM), preventing the complication of overlapping fragmentation spectra from analytes with similar nominal masses. The resulting MS/MS spectra are easier to interpret and significant database search hits are more readily achieved.

High Sensitivity/Resolution
Near axis laser irradiation provides enhanced ion transmission and sensitivity in all modes of operation. The unique reflectron design improves resolution, and enhanced calibration algorithms with easy-to-use software provide more accurate data.

Outstanding Sensitivity with an uncompromised gridless design that ensures no MS/MS signal is lost.

High-resolution MS Data in Reflectron Mode
At >20,000 FWHM, the AXIMA Performance enables more accurate and confident peptide mass fingerprinting.

Uncompromised Linear Mass Range and Sensitivity
A highly optimized linear mode generates reproducible and sensitive results for very high mass compounds and complexes, extending the array of sample classes that may be analyzed.

Low Sample Consumption allows many more MS/MS experiments to be performed on the same sample spot.

Unparalleled Flexibility
Not just another proteomics workhorse, polymers, oligonucleotides, SNPs, metabolites, carbohydrates and small molecules, among others, may all be analyzed and processed. A variety of sample target formats, including standard microtiter plate format 96 or 384 well targets, can be used.

Like all AXIMA MALDI-TOF systems, the AXIMA Performance can be fully integrated with robotic sample preparation devices, including the AccuSpot MALDI plate spotter and CHIP chemical printer, to create application-specific platforms. Integration with the CHIP creates a powerful platform for tissue imaging, while using an AXIMA instrument with a Prominence GPC system and AccuSpot results in a fully automated platform for polymer analysis that delivers quick, detailed analysis of ultra-trace substances.

• Custom ITO-coated glass slides
• New custom glass slide holder
• Metal slides for those who prefer a reusable slide option
• Mask to facilitate sample mounting and to shield regions of the glass slide during matrix deposition
• Carrier to aid optical scanning

• Dual mode (positive/negative ion) MALDI-TOF; supports MS imaging at a benchtop scale
• 200 Hz solid-state laser, 355 nm, for class-leading two billion shots per lifetime
• Load-lock chamber for fast sample introduction
• UV laser-based source cleaning (patented) – enables seamless self-cleaning of the ion optics, without breaking vacuum and requiring the removal of the ion optics
• Patented WideBore™ ion optics technology – significantly reduces contamination from the desorbed MALDI sample
• Easy routine maintenance of the ion optics
• Quiet operation (<55 dB)

• Ultrahigh sensitivity
• Detects macromolecules up to 1,500,000 Da

• Ultrahigh sensitivity
• Detects macromolecules up to 1,500,000 Da
• Stabilization of molecule using crosslinking reagent kits
• Fast, specific stabilization of protein interactions
• Also applicable for low mass applications
• Apple iPod Touch control

• Antibody characterization
• Protein complexes characterization
• Therapeutic protein aggregates
• High mass MALDI imaging
• Inhibitors of protein-protein interactions