Maldi TOF Mass Spectrometer (MALDI TOF MS)

MALDI TOF mass spectrometers (matrix-assisted laser desorption/ionization/time-of-flight) are amongst the most popular mass spec instruments in biology. They combine two technologies, the “soft” MALDI ionization source and the TOF mass analyzer. The latter measures an ion’s mass-to-charge ratio (m/z) by measuring the time it takes to reach a detector. The former volatilizes and ionizes those molecules using a laser, a target, and an organic compound called a matrix. In MALDI, a sample (for instance, a collection of tryptic peptides) is mixed with matrix, spotted and dried (crystallized) on the surface of a metal target plate. Upon irradiation with laser light, the matrix absorbs the energy and converts it to heat, which then causes the sample to ionize and explode off the plate into the mass analyzer. MALDI TOF mass spectrometers come in two basic flavors, MALDI TOF MS and MALDI TOF/TOF MS; the latter enables tandem MS (MS/MS) studies.
CompanyShimadzuShimadzuShimadzu
ItemMALDI-8020 EasyCare Benchtop Linear MALDI-TOF Mass SpectrometerAxima Confidence MALDI TOF Mass SpectrometerMegaTOF Megadalton MALDI Mass Spectrometer
Citations
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Catalog NumberMALDI-8020Axima ConfidenceMegaTOF
Price
Ionization Method(s)MALDIMALDIMALDI
Mass AnalyzerTOFTOFTOF
Resolution> 5000 FWHM – ACTH 18-39 (m/z 2465)5000 FWHM in linear mode; 15000 FWHM in reflectron mode180 to 200 kDa
Scanning SpeedInquireInquire15 sec/position
Mass Rangem/z 1 - 500,0001 kDa to 500 kDa0.01 to 1.5 Mda
DescriptionThrough innovative instrument design, the space-saving linear MALDI-8020 achieves performance specifications similar to those of larger, more expensive MALDI-TOF models but in a significantly smaller footprint. The MALDI-8020 improves laboratory efficiency and accelerates analysis through a newly ... Read More

An affordable, robust option for routine sample analysis performed manually or automatically, the AXIMA Confidence offers reliable mass information and MS/MS-derived structural detail. A linear mode enables outstanding levels of analysis of high-molecular weight samples while the reflectron mode,

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The MegaTOF has been developed by optimizing the integration of a high-performance Shimadzu linear MALDI TOF mass spectrometer with a CovalX high-mass system, allowing outstanding detection of macromolecules up to 1,500 kDa.

Features
  • Ultrahigh sensitivity
  • Detects macromolecules up to 1,500,000 Da
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