A triple-quadrupole mass spectrometer, also known as QqQ, is a tandem MS method in which the first and third quadrupoles act as mass filters and the second causes fragmentation of the analyte through interaction with a collision gas—it is a radiofrequency-only quadrupole, and can be used in either SIM or scan mode. The method can be used to obtain structural information or for quantitation. For structural mass spec, a common sequence is product ion scan, precursor ion scan, and neutral loss scan, followed by selected reaction monitoring (SRM) or multiple reaction monitoring (MRM).
Increased selectivity, improved S/N, lower limits of quantitation, wider linear range, and improved accuracy are some of the benefits of this technique, which encompasses triple-quad LC-MS, GC-MS, GC-MSD, and ICP-MS. Although QqQ is a particularly useful method for all stages of pharmaceutical development, it is a reliable option for many applications, such as clinical research, food safety, forensics, environmental, and proteomics.
Find, compare, and request a quote for triple quadrupole mass spectrometers across leading suppliers at Labcompare; including access to product citations, related published figures, and first-hand reviews from our scientific community.
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| Company | Shimadzu | Shimadzu | Shimadzu |
| Item | LCMS-8045RX Triple Quadrupole LC/MS/MS Mass Spectrometer | LCMS-8050RX Triple Quadrupole LC/MS/MS Mass Spectrometer | LCMS-8060RX Triple Quadrupole LC/MS/MS Mass Spectrometer |
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| Figures | | | |
| Catalog Number | LCMS-8045RX | LCMS-8050RX | LCMS-8060RX |
| Price | | | |
| Description | The workhorse triple quad LCMS-8045RX is ideal for routine analysis, delivering a balance of robustness, sensitivity and cost-effectiveness, making it the perfect option for production laboratories.
The heated ESI probe promotes the ionization of wide range of targeted compounds, while the The workhorse triple quad LCMS-8045RX is ideal for routine analysis, delivering a balance of robustness, sensitivity and cost-effectiveness, making it the perfect option for production laboratories.
The heated ESI probe promotes the ionization of wide range of targeted compounds, while the CoreSpray™ gas delivery system enhances reliability by increasing gas flow and improving nebulizer coaxiality.
This improves the heat distribution of the ionization source, ensuring unparalleled sample ionization, significantly enhancing the reliability of analytical data.
Key features include:
- Scan speed of 30,000 u/s
- 5 ms polarity switching time
- Ultra-fast MRM measurements up to 555 ch/sec
- IonFocus™ electrode – effectively removes matrix contaminants, resulting in lower noise levels, superior data quality and reduced maintenance needs
- Easy maintenance – designed without cables or tubes, removing the new ionization unit is simple: release a one-touch lever to open the unit and lift it out. In addition, no tools are needed to detach the needles fitted in APCI and DUIS units, allowing for easy maintenance.
- Performance Concierge – Automatically monitors system performance, provides proactive maintenance alerts, and reduces instrument downtime through predictive diagnostics.
Intuitive LabSolutions software allows for simplified instrument control, diverse data handling, and integration with regulatory compliance requirements.
Optional LabSolutions Insight data review software, supporting review-by-exception, dramatically improves the speed and efficiency of multi-analyte data analysis.
In addition, LabSolutions MRM Connect automates MRM optimization to create high sensitivity quantitative LC-MS/MS methods.
... Read More | Incorporating Shimadzu’s proprietary ultrafast technologies (UF Technologies), the triple quadrupole LCMS-8050RX offers outstanding measurement speeds and quantitative performance.
Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated Incorporating Shimadzu’s proprietary ultrafast technologies (UF Technologies), the triple quadrupole LCMS-8050RX offers outstanding measurement speeds and quantitative performance.
Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated electrospray source and ultra-efficient collision cell.
Combine with Shimadzu’s world-leading UHPLC systems for an unmatched level of performance.
Features:
- Ultrafast polarity switching (5 msec) – maintains constant quality and sensitivity with no loss of quantitative accuracy
- Ultra-high-speed scan rate of 30,000 u/sec – obtains high-quality mass spectra, even during high-speed analysis
- Ultrafast MRM transition speeds, up to 555 MRMs per second
- Heated ESI probe – promotes the ionization of wide range of targeted compounds
- CoreSpray™ gas delivery system – enhances reliability by increasing gas flow and improving nebulizer coaxiality
- High-efficiency CID cell – maintains signal intensity and suppresses crosstalk, even for high-speed or simultaneous multicomponent analysis
- Performance Concierge – Automatically monitors system performance, provides proactive maintenance alerts, and reduces instrument downtime through predictive diagnostics
- Easy maintenance – Changing the ESI capillary and the desolvation line (DL) can be quickly replaced without breaking vacuum
Intuitive LabSolutions software allows for simplified instrument control, diverse data handling, and integration with regulatory compliance requirements.
Optional LabSolutions Insight data review software, supporting review-by-exception, dramatically improves the speed and efficiency of multi-analyte data analysis.
In addition, LabSolutions MRM Connect automates MRM optimization to create high sensitivity quantitative LC-MS/MS methods.
... Read More | The triple quad LCMS-8060RX utilizes proprietary technologies and more efficient ion transfer to achieve outstanding speed and sensitivity.
A heat-assisted electrospray ionization probe delivers a highly efficient desolvation process that promotes the ionization of a wide range of target compounds The triple quad LCMS-8060RX utilizes proprietary technologies and more efficient ion transfer to achieve outstanding speed and sensitivity.
A heat-assisted electrospray ionization probe delivers a highly efficient desolvation process that promotes the ionization of a wide range of target compounds while the systems unique IonFocus™ electrode efficiently delivers ions into the mass spectrometer, resulting in lower noise levels, superior data quality and reduced maintenance needs.
Additional features include:
- CoreSpray™ gas delivery system – enhances reliability by increasing gas flow and improving nebulizer coaxiality.
- Ultrafast high-voltage power supply – enables sensitive and stable signal detection
- UFsweeper Collision Cell – delivers fast and accurate MRM quantitation; high-speed and high-efficiency CID occurs as ions are accelerated through the cell, enabling multi-component analysis with little signal degradation or crosstalk
- Scan speed of 30,000 u/s
- 5 ms polarity switching time
- Ultra-fast MRM measurements up to 555 ch/sec
- IonFocus™ electrode – effectively removes matrix contaminants, resulting in lower noise levels, superior data quality and reduced maintenance needs
- Easy maintenance – Consumable parts like the ESI spray needle and the inlet desolvation line (DL) can be changed quickly and easily without breaking vacuum.
- Performance Concierge – Automatically monitors system performance, provides proactive maintenance alerts, and reduces instrument downtime through predictive diagnostics.
LabSolutions LCMS workstation software offers total operator support, from analysis to data processing.
The LabSolutions Connect/LabSolutions Insight platform supports the entire analysis workflow, including:
- Project file management
- Optimization of MRM and interface parameters
- Efficient verification of quantitative results
- Simple method and batch creation
- Verification of quantitative results
... Read More |
| Ionization Method(s) | ESI, APCI, Dual Ionization, Micro-ESI | ESI, APCI, Dual Ionization, Micro-ESI | ESI, APCI, Dual Ionization, Micro-ESI |
| Mass Analyzer | Q1 & Q3 are molybdenum hyperbolic mass filters with pre-rods; Q1 includes post-rods | Q1 & Q3 are molybdenum hyperbolic mass filters with pre-rods; Q1 includes post-rods | Q1 & Q3 are molybdenum hyperbolic mass filters with pre-rods; Q1 includes post-rods |
| Mass Range | Inquire | 2 to 2000 m/z | m/z 2 to 2,000 |
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