Triple Quadrupole Mass Spectrometer (QqQ MS)

A triple-quadrupole mass spectrometer, also known as QqQ, is a tandem MS method in which the first and third quadrupoles act as mass filters and the second causes fragmentation of the analyte through interaction with a collision gas—it is a radiofrequency-only quadrupole, and can be used in either SIM or scan mode. The method can be used to obtain structural information or for quantitation. For structural mass spec, a common sequence is product ion scan, precursor ion scan, and neutral loss scan, followed by selected reaction monitoring (SRM) or multiple reaction monitoring (MRM). Increased selectivity, improved S/N, lower limits of quantitation, wider linear range, and improved accuracy are some of the benefits of this technique, which encompasses triple-quad LC-MS, GC-MS, GC-MSD, and ICP-MS. Although QqQ is a particularly useful method for all stages of pharmaceutical development, it is a reliable option for many applications, such as clinical research, food safety, forensics, environmental, and proteomics.

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CompanyShimadzuShimadzuShimadzuShimadzu
ItemLCMS-8060 NX Triple Quadrupole LC/MS/MS Mass SpectrometerLCMS-8045 Triple Quadrupole LC/MS/MS Mass SpectrometerLCMS-8050 Triple Quadrupole LC/MS/MS Mass SpectrometerLCMS-8060 Triple Quadrupole LC/MS/MS Mass Spectrometer
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Catalog NumberLCMS-8060 NXLCMS-8045LCMS-8050LCMS-8060
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DescriptionShimadzu's most powerful tandem mass spectrometer, the triple quad LCMS-8060NX utilizes proprietary technologies and more efficient ion transfer to achieve outstanding speed and sensitivity. Incorporation of a new IonFocus electrospray unit and newly designed ion guides deliver robust operation ... Read MoreThe workhorse triple quad LCMS-8045 is designed to analyze samples around the clock, making it the perfect option for production laboratories. The heated ESI probe, high-temperature heating block, heated desolvation line, drying gas, and focusing optics all act to maximize sensitivity while ... Read MoreIncorporating Shimadzu’s proprietary ultrafast technologies (UF Technologies), the triple quadrupole LCMS-8050 offers outstanding measurement speeds and quantitative performance. Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated ... Read MoreWith improved ion focusing technology, and incorporating Shimadzu’s proprietary ultrafast technologies, the LCMS-8060 creates a meaningful impact on trace quantitative detection. Combined with a robust design and easy maintenance, the LCMS-8060 is an ideal solution for better data quality and higher... Read More
Ionization Method(s)ESI probe with focus electrodesHeated ESI ProbeESI, APCI, Dual IonizationESI, APCI, Dual Ionization
Mass AnalyzerTriple quadrupoleTriple quadrupoleQ1 & Q3 are molybdenum hyperbolic mass filters with pre-rods; Q1 includes post-rodsQ1 & Q3 are molybdenum hyperbolic mass filters with pre-rods; Q1 includes post-rods
Mass Rangem/z 2 to 2,000m/z 2 to 2,0002 to 2000 m/z2 to 2000 m/z
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