| Ionization Method(s) | Micro-ESI | ESI, APCI, Dual Ionization, Micro-ESI | ESI, APCI, Dual Ionization, Micro-ESI | ESI, APCI, Dual Ionization |
| Description | Covering the complete range from micro (0.1 µL/min) to semi-micro (500 µL/min), Nexera Mikros allows operators to realize high sensitivity with the reliability and ruggedness of HPLC. A newly designed micro ESI source provides greater than ten times the sensitivity of standard UHPLC-MS Covering the complete range from micro (0.1 µL/min) to semi-micro (500 µL/min), Nexera Mikros allows operators to realize high sensitivity with the reliability and ruggedness of HPLC. A newly designed micro ESI source provides greater than ten times the sensitivity of standard UHPLC-MS systems, while the system’s UF-Link allows operators to correctly and easily connect any microflow column to ensure a zero-dead volume connection every time.
- Sensitivity gains of greater than 10X can be seen over conventional LCMS for assays of small molecules, peptides and proteins.
- Micro-ESI LCMS source designed for optimal sensitivity and ease of use. An X–Y adjustable stage and viewing camera allow for easy ESI spray needle adjustment
- Column oven mounted on the LCMS to minimize the volume between the exit of the column and the ESI needle.
- Proprietary UF-Link technology makes robust and correct connections of microflow columns a breeze
- Fast, accurate, reproducible autosampler with extremely low carry-over; injection volume ranges from 0.1 to 50 µL
- Consistent peak retention times and peak areas
... Read More | Incorporating Shimadzu’s proprietary ultrafast technologies (UF Technologies), the triple quadrupole LCMS-8050RX offers outstanding measurement speeds and quantitative performance.
Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated Incorporating Shimadzu’s proprietary ultrafast technologies (UF Technologies), the triple quadrupole LCMS-8050RX offers outstanding measurement speeds and quantitative performance.
Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated electrospray source and ultra-efficient collision cell.
Combine with Shimadzu’s world-leading UHPLC systems for an unmatched level of performance.
Features:
- Ultrafast polarity switching (5 msec) – maintains constant quality and sensitivity with no loss of quantitative accuracy
- Ultra-high-speed scan rate of 30,000 u/sec – obtains high-quality mass spectra, even during high-speed analysis
- Ultrafast MRM transition speeds, up to 555 MRMs per second
- Heated ESI probe – promotes the ionization of wide range of targeted compounds
- CoreSpray™ gas delivery system – enhances reliability by increasing gas flow and improving nebulizer coaxiality
- High-efficiency CID cell – maintains signal intensity and suppresses crosstalk, even for high-speed or simultaneous multicomponent analysis
- Performance Concierge – Automatically monitors system performance, provides proactive maintenance alerts, and reduces instrument downtime through predictive diagnostics
- Easy maintenance – Changing the ESI capillary and the desolvation line (DL) can be quickly replaced without breaking vacuum
Intuitive LabSolutions software allows for simplified instrument control, diverse data handling, and integration with regulatory compliance requirements.
Optional LabSolutions Insight data review software, supporting review-by-exception, dramatically improves the speed and efficiency of multi-analyte data analysis.
In addition, LabSolutions MRM Connect automates MRM optimization to create high sensitivity quantitative LC-MS/MS methods.
... Read More | The triple quad LCMS-8060RX utilizes proprietary technologies and more efficient ion transfer to achieve outstanding speed and sensitivity.
A heat-assisted electrospray ionization probe delivers a highly efficient desolvation process that promotes the ionization of a wide range of target compounds The triple quad LCMS-8060RX utilizes proprietary technologies and more efficient ion transfer to achieve outstanding speed and sensitivity.
A heat-assisted electrospray ionization probe delivers a highly efficient desolvation process that promotes the ionization of a wide range of target compounds while the systems unique IonFocus™ electrode efficiently delivers ions into the mass spectrometer, resulting in lower noise levels, superior data quality and reduced maintenance needs.
Additional features include:
- CoreSpray™ gas delivery system – enhances reliability by increasing gas flow and improving nebulizer coaxiality.
- Ultrafast high-voltage power supply – enables sensitive and stable signal detection
- UFsweeper Collision Cell – delivers fast and accurate MRM quantitation; high-speed and high-efficiency CID occurs as ions are accelerated through the cell, enabling multi-component analysis with little signal degradation or crosstalk
- Scan speed of 30,000 u/s
- 5 ms polarity switching time
- Ultra-fast MRM measurements up to 555 ch/sec
- IonFocus™ electrode – effectively removes matrix contaminants, resulting in lower noise levels, superior data quality and reduced maintenance needs
- Easy maintenance – Consumable parts like the ESI spray needle and the inlet desolvation line (DL) can be changed quickly and easily without breaking vacuum.
- Performance Concierge – Automatically monitors system performance, provides proactive maintenance alerts, and reduces instrument downtime through predictive diagnostics.
LabSolutions LCMS workstation software offers total operator support, from analysis to data processing.
The LabSolutions Connect/LabSolutions Insight platform supports the entire analysis workflow, including:
- Project file management
- Optimization of MRM and interface parameters
- Efficient verification of quantitative results
- Simple method and batch creation
- Verification of quantitative results
... Read More | The Nexera QX Multiplex LC-MS/MS System uses multiple, alternating sample introduction streams for continuous operation of the mass spectrometer to significantly increase laboratory throughput and profitability.
- Multiple stream technology eliminates waiting for column equilibration and system
The Nexera QX Multiplex LC-MS/MS System uses multiple, alternating sample introduction streams for continuous operation of the mass spectrometer to significantly increase laboratory throughput and profitability.
- Multiple stream technology eliminates waiting for column equilibration and system flushing
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UHPLC autosamplers, stream-dedicated injection valves and washing pumps deliver ultra-fast performance with ultra-low carryover
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Automates flow line rinsing of each analytical stream to mitigate carryover from extreme samples
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Online sample cleanup – Automated online sample preparation avoids errors caused by manual handling and maximizes throughput.
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Multiple configurations available
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Utilizes the LCMS-8060NX triple quadrupole mass spectrometer, which delivers industry-leading robustness, sensitivity and detection speeds.
Dedicated QX Solution software offers a single point of control for multiple UHPLC streams and the mass spectrometer. By incorporating Analytical Intelligence, such as automatic carryover detection and evaluation, automatic rinsing, and high-concentration automatic detection, QX software ensures robust operation for prolonged unattended analysis.... Read More |