Capillary electrophoresis instruments enable to the separation of charged molecules from each other. Unlike standard SDS-PAGE separation, capillary electrophoresis systems can provide molecule detection after separation through a light source and detector and the system can utilize high voltages without overheating the samples. Applications for capillary electrophoresis instruments include pharmaceutical (i.e. digest analysis of biopharma drugs; peptide mapping), life science (i.e., protein/peptide separation, DNA analysis, and PCR product analysis, chemical (i.e. raw material analysis), forensics (i.e. drug and explosive analysis), environmental (i.e. pesticide analysis) and food/beverage (i.e. as organic acid analysis).
Consideration when purchasing a capillary electrophoresis system:
Capillary electrophoresis provides additional advantages over other analysis methods, like HPLC, GC, SDS-PAGE, which include speed, cost of analysis, and easy method development. First consideration is the type of system required. There are several methods of capillary electroseparation, which include capillary zone electrophoresis, capillary isoelectric focusing, capillary gel electrophoresis, and more. Second consideration is the system’s throughput; how many samples can the instrument run.
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| Company | Agilent Technologies | Agilent Technologies | Agilent Technologies | Agilent Technologies |
| Item | ProteoAnalyzer System | Fragment Analyzer Systems | Oligo Pro II System | ZAG DNA Analyzer System |
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| Catalog Number | M5350AA | M5310AA / M5311AA / M5312AA | M5340AA | M5320AA |
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| Description | The Agilent ProteoAnalyzer system is a parallel capillary electrophoresis instrument that automates the capillary electrophoresis-sodium dodecyl sulfate (CE-SDS) analysis of reduced and non-reduced protein samples. Able to separate 12 samples in as little as 30 minutes, this system is designed to The Agilent ProteoAnalyzer system is a parallel capillary electrophoresis instrument that automates the capillary electrophoresis-sodium dodecyl sulfate (CE-SDS) analysis of reduced and non-reduced protein samples. Able to separate 12 samples in as little as 30 minutes, this system is designed to eliminate the laborious process of SDS-PAGE gel preparation, staining/destaining, and analysis so you can focus on results.
The ProteoAnalyzer system separates proteins from 10 to 240 kDa allowing for the analysis of proteins over a wide range of sizes in a single run. The discrete individual capillaries are rejuvenated between every separation allowing for the analysis of diverse samples including monoclonal antibodies, biosimilars, protein purification fractions, and crude lysates.
Features: - Short analysis time— Analyze 12 protein samples in parallel in as little as 30 minutes
- Various sample types— Consistently separate challenging protein samples such as membrane proteins and crude lysates
- High separation resolution— Resolve glycosylated and non-glycosylated isoforms
- Broad sizing range— Agilent Protein Broad Range P240 kit for sizing proteins from 10 to 240 kDa
- High sensitivity— Detect as low as 1 ng/µL concentration of BSA protein in PBS
- Wide sample concentration range— Linear dynamic range of 2 - 2,000 ng/µL BSA sample in PBS
- Improved lab efficiency— Load samples and program next runs while a separation is currently in process
- Flexible sample loading— Move samples up or down in queue to adjust run priorities
- Minimal instrument preparation— Does not require daily array handling and utilizes room-temperature stable reagents
... Read More | The Agilent Fragment Analyzer systems employ several unique design features to alleviate common quality control chokepoints. These features include, increased instrument availability, flexible and dependable operations, and customizable runs helping you reachresults faster.
Using automated parallelThe Agilent Fragment Analyzer systems employ several unique design features to alleviate common quality control chokepoints. These features include, increased instrument availability, flexible and dependable operations, and customizable runs helping you reachresults faster.
Using automated parallel capillary electrophoresis, the Fragment Analyzer systems offer nucleic acid quality control for a range of applications, including NGS libraries and cfDNA QC. Simple sample preparation, automated operation, and intuitive analysis software contribute to efficient and accurate measurement.
There are three models, varying only in throughput, to fit the needs of any lab... Read More | The Agilent Oligo Pro II system delivers accurate purity assessments of ssDNA and ssRNA oligonucleotides without the use of dyes. Ensure optimum downstream performance of oligonucleotides up to 60-mer in length with n-1 resolution.
With 12-, 24-, and 96-capillary arrays available along with The Agilent Oligo Pro II system delivers accurate purity assessments of ssDNA and ssRNA oligonucleotides without the use of dyes. Ensure optimum downstream performance of oligonucleotides up to 60-mer in length with n-1 resolution.
With 12-, 24-, and 96-capillary arrays available along with three 96-well plate sample drawers, the Oligo Pro II system quickly adjusts to meet changing throughput demands. Intuitive and automated operations simplify the measurement of oligonucleotide purity and help you focus on results.
Features - Fast separations - Complete 12, 24, or 96 samples in about 1 hour
- Improve product quality - Monitor synthesis performance to demonstrate purity of ssDNA or ssRNA
- Wide sizing range - Achieve single base resolution through 60-mers
- Throughput for all labs - Variable throughput with the option of 12, 24, or 96 capillary arrays
- Direct detection of oligos - No dye labeling needed, uses UV detection
- Simplified report generation - Advanced peak integration software and data reporting capabilities
- Desktop PC supplied with a comprehensive 3-year warranty through HP
... Read More | The Agilent ZAG DNA Analyzer system relieves bottlenecks in automated high-throughput DNA fragment analysis workflows. Using parallel capillary electrophoresis, the ZAG DNA Analyzer system can process thousands of DNA fragment samples a day, eliminating bottlenecks associated with agarose gels.
The Agilent ZAG DNA Analyzer system relieves bottlenecks in automated high-throughput DNA fragment analysis workflows. Using parallel capillary electrophoresis, the ZAG DNA Analyzer system can process thousands of DNA fragment samples a day, eliminating bottlenecks associated with agarose gels.
This system is ideal for various DNA fragment applications, from basic PCR fragment analysis to microsatellite detection. Minimal sample preparation, automated separation of samples, and the option for continuous operation help keep your workflow moving.
Features - High Separation Resolution - Reliably distinguish and size DNA fragments within 3 bp of each other.
- High Throughput - Process 48, 96-well sample trays in 24 hours.
- Broad Sizing Range - Size fragments between 35 bp and 20,000 bp through a variety of available DNA analysis kits.
- Fast Separation Times - Samples can be separated in as little as 20 minutes.
- Intuitive Data Analysis - Analytical software can process separation data automatically after the run and generate a report in multiple formats.
- Desktop PC supplied with a comprehensive 3-year warranty through HP.
... Read More |
| Type | Inquire | Inquire | Inquire | Qualitative |
| Applications | Protein sizing and quantification under reduced and non-reduced conditions; antibodies analysis, membrane, secreted, purified protein, and total protein extractions analysis | Next-Gen Sequencing, PCR Fragments, Cell-Free DNA, CRISPR/Cas9, Genomic DNA, RNA Analysis | Inquire | Inquire |
| Number of Samples | 12 per run | 12 to 96 samples | 96 | 96 |
| Dimensions | (WxDxH) 35 x 51 x 61 cm | Inquire | Inquire | Inquire |
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