Single cell dispensers are specialized laboratory instruments used to isolate and dispense single cells for various analytical techniques. Often utilizing a combination of microscopy and microfluidics techniques, single cell dispensers can isolate stained or unstained cells and gently dispense cells into various-sized well plates for analysis. Single cell dispensers are an indispensable instrument for streamlining cell line development (CLD) by utilizing automation while increasing reproducibility and efficiency while ensuring monoclonality. Single cell dispensers ensure monoclonality in several different ways and the methods used should be compared to ensure compliance with your specific assay. Plate formats should also be considered as these can vary from instrument to instrument and most instruments can accommodate multiple plate sizes. Plate sizes can also affect analysis time, with higher capacity plates leading to longer analysis times. Lastly, the size of your cells should be considered, single cell dispensers are often compatible with a range of cell sizes but compatibility with your specific cell sizes should be ensured.
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| Company | CYTENA | CYTENA | CYTENA |
| Item | UP.SIGHT™ Single Cell Dispenser and Plate Imager | B.SIGHT™ Microbial Single Cell Isolation | F.SIGHT™ 2.0 Next-Gen Single Cell Dispenser with Fluorescent Sorting |
| Catalog Number | CY.US.UCA.233 | B.SIGHT | CY.US.UCA.204 |
| Price | | | |
| Description | The ultimate upgrade in cell line development.
The UP.SIGHT™ streamlines cell line development (CLD) workflows by automating labor-intensive and time-consuming steps. We have combined our patented, highly efficient, fast and gentle single-cell dispensing technology with a superfast, high-quality The ultimate upgrade in cell line development.
The UP.SIGHT™ streamlines cell line development (CLD) workflows by automating labor-intensive and time-consuming steps. We have combined our patented, highly efficient, fast and gentle single-cell dispensing technology with a superfast, high-quality imaging system that provides a full well image without image stitching. The UP.SIGHT offers two independent methods of assuring monoclonality: first, images are taken at the dispensing nozzle to ensure only one cell is placed in each well and nonclonal droplets are discarded; second, the single cells are confirmed once more with 3D Full Well Imaging, a new and innovative method that images the full volume of each well from the point of dispensing using the integrated imager, leading to a probability of clonality >99.99%.
Key features and benefits: - Double assured clonality
- Minimal cell loss
- Small footprint and benchtop
... Read More | The second generation of B.SIGHT is a microbial isolation platform that uses cutting-edge optical microscopy and our single-cell dispensing technology to enable the isolation of the smallest microbial cells. This device revolutionizes microbiology research by allowing rapid and efficient isolation The second generation of B.SIGHT is a microbial isolation platform that uses cutting-edge optical microscopy and our single-cell dispensing technology to enable the isolation of the smallest microbial cells. This device revolutionizes microbiology research by allowing rapid and efficient isolation of bacteria from complex microbiome samples or transformed yeast and/or bacteria cultures used for strain development.
Key features or benefits: - Fast high-throughput single- cell isolation and cloning of microorganism
- Isolate single bacteria/yeast in a 384-well plate in under 8 minutes
- Precise deposition of single cells onto PCR plates
- Assurance of clonality
- Can be integrated into automation workflows
... Read More | Rapid single-cell dispensing with fluorescent sorting.
The F.SIGHT™ 2.0 is our fastest single-cell dispenser capable of isolating both unlabeled and green fluorescent cells. With our patented, highly efficient, and gentle technology, single cells are dispensed into a 96-well plate in under 2 Rapid single-cell dispensing with fluorescent sorting.
The F.SIGHT™ 2.0 is our fastest single-cell dispenser capable of isolating both unlabeled and green fluorescent cells. With our patented, highly efficient, and gentle technology, single cells are dispensed into a 96-well plate in under 2 minutes, and into a 384-well plate in under 7 minutes. Its innovative dual-camera system enables you to simultaneously capture brightfield and fluorescence information at full resolution.
Key features and benefits: - Brightfield and fluorescence imaging
- Fast and gentle single cell dispensing
- Small footprint and benchtop
... Read More |
| Plate Formats | 96 or 384-well plates | 96,384-well plates | 96- or 384-well plates |
| Applications | Monoclonal cell culture, Monoclonal antibody development, Automated cell line development, Cell therapy & stem cell research, Gene Therapy | Synthetic biology, Single bacteria isolation, Single yeast isolation, Microbiome research, Anaerobic microorganism isolation | Cell line development, Gene therapy and viral vector production, Cell therapy and stem cell-based research, CRISPR gene editing, Exosome manufacturing |
| Volume | Inquire | ~50 pL | ~200 pL |
| Analysis Time | Single-cell dispensing into 96-well plate: ~2 min
Single-cell dispensing into 384-well plate: ~8 min
Single-cell dispensing plus 3D Full Well Imaging 384-well plate: ~25 min
Well bottom imaging of 96-well plate: ~8 min
Well bottom imaging of 384-well plate: ~8 min
| Single-cell dispensing 96-well plate: ~ 3 min
Single-cell dispensing 384-well plate: ~ 8 min | Single-cell dispensing 96-well plate: ~ 2 min
Single-cell dispensing 384-well plate: ~ 8 min |
| Dimensions | (WxDxH) 635 x 400 x 282 mm | (WxDxH) 635 x 400 x 282 mm | (WxDxH) 635 x 400 x 282 mm |
| Cell size range | 5 to 40 µm | 0.5 to 20 µm | 5 to 40 µm |
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