The QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) extraction approach has streamlined pesticides in food analysis by hyphenated mass spectrometry. With speed and ease, however, comes the challenge of high-matrix samples that can adversely affect the performance of the instrument over time and, thus, increase maintenance requirements. Triple quadrupole GC/MS/MS analysis in a high-throughput laboratory may require that the ion source be cleaned as often as every few weeks. This poster demonstrates the use of off-line cleaning with hydrogen (between analytical runs) is optimal for analysis of pesticides in foods and increases the interval between source cleanings by several-fold.

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