Exosomes are small extracellular vesicles (EVs), 30-150 nm in diameter, which have been determined to play a crucial role in extracellular signaling. They have been observed in both prokaryotic and eukaryotic organisms, meaning they are incredibly widely spread in nature. Exosomes bud off from their parent cells in a sealed package, taking the properties of their parent cell walls with them and encasing many intracellular components. A wide variety of bioactive markers have been found encased in exosomes including but not limited to proteins, lipids, DNA, and RNA. Upon formation, exosomes are released into the extracellular space and have been found in many body fluids including: blood, urine, saliva, and breast milk.

 

The diversity of this cargo has led to exosomes having a litany of roles within the body including but not limited to: immune regulation, tissue regeneration, cancer progression, and neurodegenerative diseases. This application note examines how the ViewSizer is an excellent tool for characterizing the size and concentration of EVs and that it can detect labeled populations of fluorescently tagged exosomes with high repeatability and accuracy.

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