Liver disease affects more than 800 million people worldwide causing at least 1.5 million deaths annually. Alcohol consumption and alcoholic liver disease (ALD) continue to be a major cause of morbidity and mortality in the US. Polychlorinated biphenyls (PCBs) are persistent environmental pollutants. Exposures to PCBs have been associated with non-alcoholic fatty liver disease. Monitoring these and other diseases of the liver can be achieved by evaluating metabolites in serum or plasma but a key, basal understanding can come from evaluation of the diseased tissues themselves. Changes detected here will help understand the biology and physiology and may translate to the circulation. Mice provide a good model for this type of research.

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