Description
The Calypso™ composition-gradient system and CALYPSO™ software combine with a DAWNTM or miniDAWN™ MALS instrument to characterize biomolecular interactions by CG-MALS. CG-MALS is a label-free, immobilization-free technique that measures the change in apparent molecular weight with composition and concentration in order probe protein-protein binding and other interactions.
Calypso’s unique software analyzes self- and hetero-association, non-specific interactions(both attractive and repulsive), reversible and irreversible kinetics of aggregation and dissociation A comprehensive variety of interaction parameters including equilibrium dissociation constants, absolute complex stoichiometry, virial coefficients (A2) and cross-virial coefficients (A11), and reaction rates can be determined using CG-MALS.