Laboratory autoclaves sterilize laboratory equipment by using high temperatures and pressure to produce steam. Autoclaves are found in research labs, medical environments, dental offices, and anywhere else where microbial contamination is a primary concern. When loading an autoclave, it is important the instruments not be touching each other so the steam can access every surface point. Some things to consider when purchasing an autoclave sterilizer are how much equipment the machine can hold, the temperature and pressure range, and if cooling is an option.