| Description | Method scouting is a process where different mobile phases and column stationary phases are evaluated to determine the best set of separation conditions for a particular sample. Manual solvent preparation, column switching, and method programming are time-consuming steps, so the Nexera method Method scouting is a process where different mobile phases and column stationary phases are evaluated to determine the best set of separation conditions for a particular sample. Manual solvent preparation, column switching, and method programming are time-consuming steps, so the Nexera method scouting system was developed to streamline the entire process for more efficient method development.
The system is based around 2 LC-30AD pumps, each with a quaternary valve, which allows the analyst to run binary gradients with 16 different solvent pairs. A high-pressure column selection valve holds from 1 to 6 columns, resulting in up to 96 unique separation conditions per sample. Ultra-high speed conditions can be easily transferred to conventional conditions using a transfer program. In addition, scouting is performed automatically when the mobile phase is switched.
The Nexera Method Scouting Solution software has intuitive, user-friendly screens to set the pump and column valve positions, gradient program steps, and it automatically builds the sequence table in seconds. Method Scouting Solution provides the data required for analysis via a graphical user interface, as well as automated controls conforming to laboratory operations configured in the system settings.
... Read More | This system can switch automatically between SFC analysis and UHPLC analysis and make measurements on a single sample in each separation mode. It enhances user-friendliness and efficiency by allowing the investigation of separation conditions and performing reverse-phase high-speed analysis in a This system can switch automatically between SFC analysis and UHPLC analysis and make measurements on a single sample in each separation mode. It enhances user-friendliness and efficiency by allowing the investigation of separation conditions and performing reverse-phase high-speed analysis in a single system.
Key benefits:
- Enables both UHPLC and SFC analysis using a single system
- Reduces laboratory space requirements and equipment costs
- Existing UHPLC can be upgraded to an SFC/LC Switching System
- Method Scouting Solution software automates and manages method development analyses; switching from UHPLC to SFC conditions is performed without user intervention
- Reliable analysis even when switching between SFC and UHPLC modes
... Read More | Nexera X3 excels in high throughput environments requiring fast separations. The system easily handles small ID UHPLC columns with sub-2 micron particles for high efficiency chromatography. Five-minute run times are the norm. With Analytical Intelligence functions, the system makes lab management Nexera X3 excels in high throughput environments requiring fast separations. The system easily handles small ID UHPLC columns with sub-2 micron particles for high efficiency chromatography. Five-minute run times are the norm. With Analytical Intelligence functions, the system makes lab management simple, enabling users to easily review instrument status, optimize resource allocation, and achieve higher throughput.
Key features and benefits include:
- High efficiency chromatography with 130 MPa (~19,000 psi) pressure tolerance and LPGE or HPGE solvent delivery
- Ultra-fast injection cycles (7 sec) with ultralow carryover
- High capacity sample handling
- Optional dual-injection system
- Outstanding baseline stability and linearity (2.5 AU), even under fluctuating temperatures
- Plate changers enable non-stop temperature-controlled analysis of thousands of samples
- Allows remote monitoring in real time directly from a web browser or smart device
- Touch-panel interface allows the user to control the instrument and carry out analysis preparation directly without the need for a PC
- Analytical intelligence functions, including smart flow control, automatic startup, auto-recovery and auto-diagnostics, and real-time mobile phase monitoring
- i-PeakFinder tool – can automatically recognize peaks even in complex chromatograms with high noise, and accounts for baseline drift for higher integration accuracy
- i-PDeA II peak deconvolution function – can quantify peaks that cannot be completely separated by a column
... Read More | A truly bioinert UHPLC, the Nexera XS inert has been engineered with unique technology that ensures the complete inertness of the sample path to eliminate corrosion and adsorption in bioanalysis, hence providing newfound clarity even for challenging compounds. This reduces sample losses and enables A truly bioinert UHPLC, the Nexera XS inert has been engineered with unique technology that ensures the complete inertness of the sample path to eliminate corrosion and adsorption in bioanalysis, hence providing newfound clarity even for challenging compounds. This reduces sample losses and enables excellent sensitivity. Analysts can acquire highly reliable data from compounds prone to metal adsorption with high reproducibility. The system also improves peak shape and achieves outstanding chromatographic separation.
Key benefits:
- Bioinert flow path prevents sample loss due to adsorption
- UHPLC performance for high efficiency bioanalysis
- Corrosion-resistant material ensures long-term stability and reliable data acquisition
- Worry-free switching between multiple columns for method development or for trap-and-elute analysis without adsorption concerns
- Easy tool-free tubing connections with unique finger-tightened fittings
The dedicated LabSolutions Insight™ Software for LC/MS data analysis features functionality carefully selected to provide powerful support for multiple-component and multi-sample data analysis, such as flagging, filtering and peak comparison. For more advanced analysis, the Nexera XS inert system can be used with Analytical Intelligence technology for automatic analysis.... Read More | The Nexera XS UHPLC excels at fast separations, easily handling small ID UHPLC columns with sub-2 micron particles or the popular SPP phases for high efficiency and lower back pressure. A common XS configuration may have a 4-channel solvent selection valve on each pump providing versatility for The Nexera XS UHPLC excels at fast separations, easily handling small ID UHPLC columns with sub-2 micron particles or the popular SPP phases for high efficiency and lower back pressure. A common XS configuration may have a 4-channel solvent selection valve on each pump providing versatility for method development. Five to ten-minute run times are the norm. With Analytical Intelligence functions, the system makes lab management simple, enabling users to easily review instrument status, optimize resource allocation, and achieve higher throughput.
Key features and benefits include:
- High efficiency chromatography with 105 MPa (~15,000 psi) pressure tolerance and LPGE or HPGE solvent delivery
- Ultra-fast injection cycles (7 sec) with ultralow carryover
- High capacity sample handling
- Optional dual-injection system
- Outstanding baseline stability and linearity (2.5 AU), even under fluctuating temperatures
- Plate changers enable non-stop temperature-controlled analysis of thousands of samples
- Allows remote monitoring in real time directly from a web browser or smart device
- Touch-panel interface allows the user to control the instrument and carry out analysis preparation directly without the need for a PC
- Analytical intelligence functions, including smart flow control, automatic startup, auto-recovery and auto-diagnostics, and real-time mobile phase monitoring
- i-PeakFinder tool – can automatically recognize peaks even in complex chromatograms with high noise, and accounts for baseline drift for higher integration accuracy
- i-PDeA II peak deconvolution function – can quantify peaks that cannot be completely separated by a column
... Read More |
| Detector(s) | SPD-M20A | Inquire | UV, PDA, ELSD, Fluorescence, RID, Conductivity | UV, PDA, ELSD, Fluorescence | UV, PDA, ELSD, Fluorescence, RID, Conductivity |