High-performance liquid chromatography (HPLC) systems are used to analyze and/or purify liquid mixtures. Analytical HPLC systems are used in the food safety, pharmaceutical, and manufacturing industries, as well as in medical and research laboratories. Two of the most common types of analytical HPLC systems are normal phase HPLC and reversed phase HPLC. Normal phase uses a polar stationary phase and a non-polar mobile phase to separate components of a mixture, while reversed phase HPLC uses phases with the opposite polarities of normal phase HPLC. The sample liquid is mixed with the mobile phase and run through a column that contains the stationary phase. The way the sample moves through the column is the basis for the analysis.
Considerations for purchasing an Analytical HPLC System
To determine which analytic HPLC system is the best fit for your lab, decide which features will be needed. Multi-solvent or multi-column analysis, stationary phase pore size, possible pump pressures, possible flow rates, and number of wavelength detectors are all factors that can vary.
Discover and compare Analytical HPLC Systems:
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| Company | Shimadzu | Shimadzu | Shimadzu |
| Item | i-Series Integrated (u)HPLC Systems | 2D HPLC for Bioanalysis (Co-Sense for BA) | Hemp Analyzer |
| Citations | | | |
| Catalog Number | i-Series LC-50/60 | Co-Sense for BA | Hemp Analyzer |
| Price | | | |
| Detector(s) | UV/VIS, PDA, RI, Fluorescence, ELSD | UV, LCMS | Inquire |
| Flow Rate | 0.0001 to 10 mL/min | Inquire | Inquire |
| Max. Pressure | 70 MPa | Inquire | Inquire |
| Description | Building on the exceptional performance of previous versions, the integrated i-Series LC-2050/LC-2060 models incorporate Analytical Intelligence functions, enable complete automation from start-up to analysis preparations, and allow remote monitoring and data processing. In addition, the easy-to-useBuilding on the exceptional performance of previous versions, the integrated i-Series LC-2050/LC-2060 models incorporate Analytical Intelligence functions, enable complete automation from start-up to analysis preparations, and allow remote monitoring and data processing. In addition, the easy-to-use, easy-access front-panel interface replicates the system flow channel and simplifies the operating status of the system. Method editing can also be easily performed directly from the same screen. With this intuitive design, even users who are completely new to liquid chromatography can navigate the user interface with minimal training.
Features include:
- 14-second injection cycle to support high-speed multi-analyte processing
- Lowest carryover (<0.0025%) with exceptional reproducibility
- Increased sample capacity – autosampler accommodates over 1,500 samples
- UV or PDA detector standard; optional detectors can be added
- Forced air circulation column oven for (ambient -10) to 90 degrees temperature control
- Dual temperature-controlled optics and flow cell for excellent baseline stability
- Analytical intelligence functions, including real-time mobile phase monitoring, smart flow control, and i-PeakFinder automatic peak integration
- Easy migration of existing methods from either Shimadzu or non-Shimadzu systems
With LabSolutions Direct, analysts can operate instruments remotely and implement pre-configured methods using the web browser of a computer or a smart device. Instrument status and chromatograms can also be monitored remotely for increased efficiency and uptime.
The i-Series LC-2050/LC-2060 models feature increased pressure tolerance to enable use for a wider range of analysis conditions. The upper pressure limit for the LC-2050 is 50MPa (7,000psi), and for the LC-2060 is 70MPa (10,000psi).... Read More | Automatically and seamlessly conducting all processes from sample pre-treatment to analysis, the Prominence 2D HPLC for BA is a column-switching HPLC system equipped with the newly developed Shim-pack MAYI-ODS pretreatment column and a unique on-line dilution bypass channel. The system’s on-line preAutomatically and seamlessly conducting all processes from sample pre-treatment to analysis, the Prominence 2D HPLC for BA is a column-switching HPLC system equipped with the newly developed Shim-pack MAYI-ODS pretreatment column and a unique on-line dilution bypass channel. The system’s on-line pre-treatment of bio-samples reduces labor while enhancing efficiency. A high-throughput autosampler provides high-speed injection and reproducibility. Accurate and precise temperature control of the system further ensures reproducible analysis and a high recovery rate. Key features include: - Shim-pack MAYI-ODS Pretreatment Column – This unique column effectively removes proteins from bio-samples, achieves long-term stability through optimization of particle diameter and newly developed coating technology, and exhibits excellent repeatability
- On-line Dilution Bypass Effect – Eliminates the need for preliminary dilution of the sample by automatically diluting it on-line, leading to excellent recovery rates
- Suppression of Carryover – A number of enhancements, including a specially treated outer needle surface and improvement of needle seal composition, greatly reduce sample adsorption, critical for achieving the high sensitivity of LC-MS/MS
- Precise Temperature Control of the Pretreatment Column
This system serves as a front-end HPLC system for a mass spectrometer, enhancing the efficiency of analyzing drugs in bio-samples in pharmacokinetics studies and clinical tests. ... Read More | The Shimadzu Hemp Analyzer captures the spirit of an Analyzer – a comprehensive package integrating instrument hardware, software, consumables, and analytical workflow. Includes a certified reference material (CRM) mixture of target compounds. Also includes a service package to cover preventive The Shimadzu Hemp Analyzer captures the spirit of an Analyzer – a comprehensive package integrating instrument hardware, software, consumables, and analytical workflow. Includes a certified reference material (CRM) mixture of target compounds. Also includes a service package to cover preventive maintenance and warranty for three years, plus free technical support for the life of the product. The solution is ready to use after one day of installation and testing, and requires no time-consuming method development on the part of the analyst.
Choice of three proven HPLC methods:
- The High Throughput method is designed for analysis of CBD and 9 other commonly requested cannabinoids in under 8 minutes. This is the original method developed by Shimadzu in collaboration with industry laboratories. (Does not include THCV.)
- The High Sensitivity method adds THCV to the target analyte list, with an instrument cycle time of under 10 minutes. The short analysis time produces the sharpest chromatographic peaks for the best overall sensitivity.
- The High Resolution method presents full baseline resolution for all 11 compounds and an analysis time under 30 minutes. This method is preferred for research purposes, or when additional compounds must be added to the analysis in response to new state regulatory requirements.
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