| Description | Method scouting is a process where different mobile phases and column stationary phases are evaluated to determine the best set of separation conditions for a particular sample. Manual solvent preparation, column switching, and method programming are time-consuming steps, so the Nexera method Method scouting is a process where different mobile phases and column stationary phases are evaluated to determine the best set of separation conditions for a particular sample. Manual solvent preparation, column switching, and method programming are time-consuming steps, so the Nexera method scouting system was developed to streamline the entire process for more efficient method development.
The system is based around 2 LC-30AD pumps, each with a quaternary valve, which allows the analyst to run binary gradients with 16 different solvent pairs. A high-pressure column selection valve holds from 1 to 6 columns, resulting in up to 96 unique separation conditions per sample. Ultra-high speed conditions can be easily transferred to conventional conditions using a transfer program. In addition, scouting is performed automatically when the mobile phase is switched.
The Nexera Method Scouting Solution software has intuitive, user-friendly screens to set the pump and column valve positions, gradient program steps, and it automatically builds the sequence table in seconds. Method Scouting Solution provides the data required for analysis via a graphical user interface, as well as automated controls conforming to laboratory operations configured in the system settings.
... Read More | Automatically and seamlessly conducting all processes from sample pre-treatment to analysis, the Prominence 2D HPLC for BA is a column-switching HPLC system equipped with the newly developed Shim-pack MAYI-ODS pretreatment column and a unique on-line dilution bypass channel. The system’s on-line preAutomatically and seamlessly conducting all processes from sample pre-treatment to analysis, the Prominence 2D HPLC for BA is a column-switching HPLC system equipped with the newly developed Shim-pack MAYI-ODS pretreatment column and a unique on-line dilution bypass channel. The system’s on-line pre-treatment of bio-samples reduces labor while enhancing efficiency. A high-throughput autosampler provides high-speed injection and reproducibility. Accurate and precise temperature control of the system further ensures reproducible analysis and a high recovery rate. Key features include: - Shim-pack MAYI-ODS Pretreatment Column – This unique column effectively removes proteins from bio-samples, achieves long-term stability through optimization of particle diameter and newly developed coating technology, and exhibits excellent repeatability
- On-line Dilution Bypass Effect – Eliminates the need for preliminary dilution of the sample by automatically diluting it on-line, leading to excellent recovery rates
- Suppression of Carryover – A number of enhancements, including a specially treated outer needle surface and improvement of needle seal composition, greatly reduce sample adsorption, critical for achieving the high sensitivity of LC-MS/MS
- Precise Temperature Control of the Pretreatment Column
This system serves as a front-end HPLC system for a mass spectrometer, enhancing the efficiency of analyzing drugs in bio-samples in pharmacokinetics studies and clinical tests. ... Read More | The CBM-40 is a small-profile unit that stacks neatly with main system components. Other LC modules connect via fiber optic cables for easy "plug and play" system configuration. An internal web server offers convenient control and monitoring of the UHPLC system through a web browser, LabSolutions The CBM-40 is a small-profile unit that stacks neatly with main system components. Other LC modules connect via fiber optic cables for easy "plug and play" system configuration. An internal web server offers convenient control and monitoring of the UHPLC system through a web browser, LabSolutions CDS, or other third-party software.
Features:
- Connection via Ethernet
- Offers 4 Fiber Optic ports for controlling other system components
... Read More | Building on the exceptional performance of previous versions, the integrated i-Series LC-2050/LC-2060 models incorporate Analytical Intelligence functions, enable complete automation from start-up to analysis preparations, and allow remote monitoring and data processing. In addition, the easy-to-useBuilding on the exceptional performance of previous versions, the integrated i-Series LC-2050/LC-2060 models incorporate Analytical Intelligence functions, enable complete automation from start-up to analysis preparations, and allow remote monitoring and data processing. In addition, the easy-to-use, easy-access front-panel interface replicates the system flow channel and simplifies the operating status of the system. Method editing can also be easily performed directly from the same screen. With this intuitive design, even users who are completely new to liquid chromatography can navigate the user interface with minimal training.
Features include:
- 14-second injection cycle to support high-speed multi-analyte processing
- Lowest carryover (<0.0025%) with exceptional reproducibility
- Increased sample capacity – autosampler accommodates over 1,500 samples
- UV or PDA detector standard; optional detectors can be added
- Forced air circulation column oven for (ambient -10) to 90 degrees temperature control
- Dual temperature-controlled optics and flow cell for excellent baseline stability
- Analytical intelligence functions, including real-time mobile phase monitoring, smart flow control, and i-PeakFinder automatic peak integration
- Easy migration of existing methods from either Shimadzu or non-Shimadzu systems
With LabSolutions Direct, analysts can operate instruments remotely and implement pre-configured methods using the web browser of a computer or a smart device. Instrument status and chromatograms can also be monitored remotely for increased efficiency and uptime.
The i-Series LC-2050/LC-2060 models feature increased pressure tolerance to enable use for a wider range of analysis conditions. The upper pressure limit for the LC-2050 is 50MPa (7,000psi), and for the LC-2060 is 70MPa (10,000psi).... Read More | The modular LC-40 system is the workhorse for everyday HPLC, whether using traditional 5 micron fully porous LC columns or the popular SPP column phases for high efficiency separations with lower back pressures. With Analytical Intelligence functions, the system makes lab management simple, enablingThe modular LC-40 system is the workhorse for everyday HPLC, whether using traditional 5 micron fully porous LC columns or the popular SPP column phases for high efficiency separations with lower back pressures. With Analytical Intelligence functions, the system makes lab management simple, enabling users to easily review instrument status, optimize resource allocation, and achieve higher throughput.
Key features and benefits include:
- High efficiency chromatography with 44 MPa (~6,000 psi) pressure tolerance and LPGE or HPGE solvent delivery
- Ultra-fast injection cycles (7 sec) with ultralow carryover
- High capacity sample handling
- Optional dual-injection system
- Outstanding baseline stability and linearity (2.5 AU), even under fluctuating temperatures
- Plate changers enable non-stop temperature-controlled analysis of thousands of samples
- Allows remote monitoring in real time directly from a web browser or smart device
- Touch-panel interface allows the user to control the instrument and carry out analysis preparation directly without the need for a PC
- Analytical intelligence functions, including smart flow control, automatic startup, auto-recovery and auto-diagnostics, and real-time mobile phase monitoring
- i-PeakFinder tool – can automatically recognize peaks even in complex chromatograms with high noise, and accounts for baseline drift for higher integration accuracy
- i-PDeA II peak deconvolution function – can quantify peaks that cannot be completely separated by a column
... Read More |