Dynamic Light Scattering Particle Size Analysis (DLS)

Dynamic light scattering particle size analyzers are used to measure the size of very small particles (0.6 nm to 6 um) in solution. This class of particle size analyzer interprets particles’ sizes from the fluctuations in scattered laser light created by the particles’ Brownian motion. Dynamic light scattering analysis is used in medical, biological research and materials science applications, and is also known as photon correlation spectroscopy or quasi-electron light scattering.

Although requiring suspension in a solution, particle size analysis by dynamic light scattering offers the advantage of measuring particles across a wide range of densities, from parts-per-million up to 40% of solution. Other advantages include size analysis of particles in their native environment and micro-liter scale minimum sample sizes. In addition, dynamic light scattering particle size analyzers may also provide information on particle shape and require less user training. Analysis times typically vary from 30 seconds to 2 minutes per sample.
CompanyWaters | Wyatt TechnologyWaters | Wyatt TechnologyWaters | Wyatt TechnologyWaters | Wyatt Technology
ItemWyattQELS™ Light Scattering Detector ModuleDynaPro™ NanoStar™ II Dynamic Light Scattering InstrumentDynaPro™ Plate Reader III Dynamic Light Scattering InstrumentDynaPro™ ZetaStar™ Dynamic, Electrophoretic, and Static Light Scattering Instrument
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Catalog NumberWyattQELSDynaPro NanoStar IIDynaPro Plate reader IIIDynaPro ZetaStar
Price
DescriptionThe WyattQELS™ dynamic light scattering (DLS) module integrates into a DAWN™, miniDAWN™ or microDAWN™ online multi-angle light scattering (MALS) instrument in order to determine high-resolution particle size distributions, when used in conjunction with a separation technique ... Read MoreThe DynaPro™ NanoStar™ II is the only DLS instrument to provide a fully integrated, walk-up measurement experience so even novices can immediately measure particle concentration, characterize size, aggregation, quality solubility, and stability of proteins, viruses, or nanoparticles in ... Read MoreThe DynaPro™ Plate Reader III is a high-throughput DLS instrument that delivers rapid measurements of particle size, concentration, aggregation, and stability of many different macromolecular or nanoparticle samples. It enables fully-automated screening of processing or formulation conditions ... Read MoreUnique among its peers, the DynaPro™ Zetastar™ performs simultaneous dynamic and static light scattering or dynamic and electrophoretic light scattering (DLS/SLS/ELS) measurements all within one instrument. Measure manually with microcuvettes, or automatically via an autosampler and flow... Read More
TypeDynamic Light ScatteringDynamic Light Scattering (DLS) and Static Light Scattering (SLS)Dynamic Light Scattering / Static Light ScatteringDynamic Light Scattering (DLS), Electrophoretic Light Scattering (ELS), Static Light Scattering (SLS)
Particle SizeFlow mode: 1 nm to 40 nm (TREOS); 1 nm to 300 (HELEOS)
Batch mode: 10 to 50 nm; 0.5 nm to 1 µm (cut 10 to 50 nm)
0.2 to 1000 nm0.5 to 1000 nm0.2 to 1000 nm
Detector(s)Avalanche photodiode coupled to a multimode optical fiberInquireLinearized avalanche photodiode for dynamic and static light scatteringInquire
Measuring TimeMeasurement Time: 0.1 to 3600 sec
Same as MALS host instrument
InquireMeasurement Time: 5 to 60 seconds per well
830 nm
15 seconds typical
Light SourceUses the host MALS instrument's laser, usually a 658 nm laser.Inquire830 nm, fiber-coupled diode laser785 nm laser, programmable 10% to 100%
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