Electrospray ionization mass spectrometers (ESI MS) use a so-called “soft” ionization technique that has found widespread use in biological mass spectrometry. Soft ionization techniques enable the ionization of large biological molecules (such as proteins) without fragmenting them, meaning they can be analyzed intact. In an electrospray ionization mass spectrometer, the molecules to be analyzed pass into the mass spectrometer in a fine spray, typically following chromatographic separation, whether via traditional liquid chromatography, HPLC, or nano-LC. As the spray emerges from the ESI source, the molecules are ionized by the nozzle’s electrically charged tip. As this mist travels and evaporates, electrostatic repulsion between like-charged ions ultimately forces the molecules apart. They then may be analyzed by a wide variety of mass analyzers, including quadrupoles, ion traps, time-of-flight, and Fourier transform-based instruments.
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Company | Shimadzu | Shimadzu | Shimadzu |
Item | LCMS-2020 Single Quadrupole Mass Spectrometer | LCMS-8050 Triple Quadrupole LC/MS/MS Mass Spectrometer | LCMS-8060 Triple Quadrupole LC/MS/MS Mass Spectrometer |
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Catalog Number | LCMS-2020 | LCMS-8050 | LCMS-8060 |
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Mass Analyzer | Single Quadrupole | Q1 & Q3 are molybdenum hyperbolic mass filters with pre-rods; Q1 includes post-rods | Q1 & Q3 are molybdenum hyperbolic mass filters with pre-rods; Q1 includes post-rods |
Ionization Method(s) | ESI, APCI, Dual Ionization | ESI, APCI, Dual Ionization | ESI, APCI, Dual Ionization |
Resolution | R = 2 M | R < 0.7 u FWHM | R < 0.7 u FWHM |
Description | Utilizing patented ultrafast (UF) technology, the LCMS-2020 mass spectrometer offers faster measurements and higher detection sensitivity for quicker and more accurate detection of trace impurities in a variety of applications.
Features - Ultrafast scanning speed of 15,000 u/sec, without
Utilizing patented ultrafast (UF) technology, the LCMS-2020 mass spectrometer offers faster measurements and higher detection sensitivity for quicker and more accurate detection of trace impurities in a variety of applications.
Features - Ultrafast scanning speed of 15,000 u/sec, without sacrificing sensitivity or resolution
- Unsurpassed 15 msec polarity switching speed, for the most data without peak deterioration in a single injection
- Multiple Ionization options – ESI, APCI, and DUIS
- Dual Ion Source – truly enables simultaneous ESI and APCI analysis
- Easy system maintenance – enables greater uptime and usability
- Innovative ion optics—provide greater sensitivity than any other single quadrupole analyzer
- Backwards compatible – no need to upgrade your HPLC
The ESI method typically used for LCMS can be replaced with APCI, which is suitable for neutral compounds, or with a dual ionization source (DUIS) for simultaneous operation of both ionization modes, quickly and without tools. Selection of the DUIS ionization mode (ESI or APCI) can be performed via the computer. In addition, the desolvation line, where the ions enter the MS unit, can be replaced without breaking vacuum.... Read More | Incorporating Shimadzu’s proprietary ultrafast technologies (UF Technologies), the triple quadrupole LCMS-8050 offers outstanding measurement speeds and quantitative performance. Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated Incorporating Shimadzu’s proprietary ultrafast technologies (UF Technologies), the triple quadrupole LCMS-8050 offers outstanding measurement speeds and quantitative performance. Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated electrospray source and ultra-efficient collision cell.. Combine with Shimadzu’s world-leading UHPLC systems for an unmatched level of performance.
Features:- Ultrafast polarity switching (5 msec) – maintains constant quality and sensitivity with no loss of quantitative accuracy
- Ultra-high-speed scan rate of 30,000 u/sec – obtains high-quality mass spectra, even during high-speed analysis
- Ultrafast MRM transition speeds, up to 555 MRMs per second
- Newly developed heated ESI probe facilitates ionization – allows for high-sensitivity analysis of a wide range of compounds
- High-efficiency CID cell – maintains signal intensity and suppresses crosstalk, even for high-speed or simultaneous multicomponent analysis
Intuitive LabSolutions software allows for simplified instrument control, diverse data handling, and integration with regulatory compliance requirements. In addition, optional LabSolutions Insight data review software, supporting review-by-exception, dramatically improves the speed and efficiency of multi-analyte data analysis.... Read More | With improved ion focusing technology, and incorporating Shimadzu’s proprietary ultrafast technologies, the LCMS-8060 creates a meaningful impact on trace quantitative detection. Combined with a robust design and easy maintenance, the LCMS-8060 is an ideal solution for better data quality and higherWith improved ion focusing technology, and incorporating Shimadzu’s proprietary ultrafast technologies, the LCMS-8060 creates a meaningful impact on trace quantitative detection. Combined with a robust design and easy maintenance, the LCMS-8060 is an ideal solution for better data quality and higher throughput. The instrument’s redesigned UF-Qarray features highly effective ion focusing capabilities. This technology helps reduce electrode contamination that can lead to poor instrument performance. Because the instrument stays clean and free of contaminants, the LCMS-8060 can provide highly reliable data even for long, continuous analysis of potentially contaminated items like biological and food samples.
The LCMS-8060 incorporates a number of UF Technologies to enable the highest levels of analytical throughput and high-speed acquisition of both quantitative and qualitative data in a single run. These technologies provide for: - a scan speed of 30,000 u/sec while maintaining mass accuracy
- multiple reaction monitoring (MRM) speeds of 555 ch/sec
- polarity switching speed of 5 msec., which ensures highly reproducible data and provides sufficient data points for the narrowest peaks.
The instrument is designed for durability and easy operation and maintenance to reduce downtime. The ionization unit features a cable-free, tubeless housing for convenience when switching from ESI to APCI or dual ionization mode. In addition, the desolvation capillary can be replaced without breaking vacuum, allowing for greater uptime and usability.
The LCMS-8060 is operated using Shimadzu’s LabSolutions software, an intuitive package that allows for simplified instrument control, diverse data handling, and integration with regulatory compliance requirements. In addition, it has been enhanced for better MRM optimization and synchronized survey scanning (SSS). In addition, optional LabSolutions Insight data review software, supporting review-by-exception, dramatically improves the speed and efficiency of multi-analyte data analysis.... Read More |
Mass Range | m/z 10 to 2000 | 2 to 2000 m/z | 2 to 2000 m/z |
Scanning Speed | 15,000 u/sec | 30,000 u/sec | 30,000 u/sec |
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