Time-of-flight mass spectrometers (TOF MS) do exactly what their name suggests: determine an ion’s mass-to-charge ratio (m/z) based on how long it takes for that ion to travel down the instrument’s “flight tube” and reach the detector. Frequently, though not exclusively coupled to matrix-assisted laser desorption ionization (MALDI) sources, TOF MS come in a variety of configurations, including a single-stage time-of-flight mass spectrometer, a multi-stage TOF/TOF, and even a hybrid quadrupole-TOF (Q-TOF) instrument; the latter two enable MS/MS applications. Often, time-of-flight mass spectrometers contain two detectors: a linear detector at the end of the flight tube, and a “reflector” detector, which captures ions that were redirected back towards the source by a “reflectron.” The reflectron serves two purposes: correcting for discrepancies in initial kinetic energy of identically sized molecules (which would cause them to reach the detector at different times and thus, have different apparent m/z values) and lengthening the flight path, improving resolution.
Find, compare, and request a quote for time of flight mass spectrometers across leading suppliers at Labcompare; including access to product citations, related published figures, and first-hand reviews from our scientific community.
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Company | SCIEX | SCIEX |
Item | X500R QTOF system | ZenoTOF 7600 system |
Citations | | |
Catalog Number | X500R QTOF | ZenoTOF 7600 |
Price | | |
Ionization Method(s) | Turbo V ion source with twin sprayer ESI probe and twin sprayer APCI probe | APCI and ESI modes |
Mass Analyzer | QTOF | TOF |
Resolution | Equal to or greater than 42,000 (FWHM) measured on the (M+6H)6+ charge isotope cluster for bovine insulin at m/z 956 | Equal to or greater than 42,000 (FWHM) measured on the [M+6H]6+ charge isotope cluster for bovine insulin at m/z 956 |
Scanning Speed | Up to 25 Hz (25 spectra per second) | up to 25 Hz (25 spectra per second) |
Mass Range | TOF: 40 kDa
Precursor Ion Selection: 5–2250 m/z | TOF: 40 kDa
Precursor Ion Selection: 5–2250 m/z |
Description | Engineered for standard biotherapeutic characterization analyses, the X500B QTOF system is a true benchtop instrument, with streamlined processing to get to a consistent, accurate view of your biologic. It is optimized for intact mass analysis, subunit analysis as well as high-quality peptide Engineered for standard biotherapeutic characterization analyses, the X500B QTOF system is a true benchtop instrument, with streamlined processing to get to a consistent, accurate view of your biologic. It is optimized for intact mass analysis, subunit analysis as well as high-quality peptide mapping workflows.... Read More | A powerful leap in proprietary innovation, this high-resolution accurate mass system combines the power of Zeno trap pulsing with EAD fragmentation technology (electron activated dissociation) to uncover structural information, previously inaccessible, and drive the limits of quantification A powerful leap in proprietary innovation, this high-resolution accurate mass system combines the power of Zeno trap pulsing with EAD fragmentation technology (electron activated dissociation) to uncover structural information, previously inaccessible, and drive the limits of quantification achievable with accurate mass.... Read More |
Quantity | EA | EA |
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