Quadrupole mass spectrometers are perhaps the simplest of mass spec instruments. Functioning effectively like a radio, the quadrupole MS – so-named because of its four charged rods, which run parallel to the flight paths of the ions it measures – filter ions by mass-to-charge ratio (m/z) by altering the voltages in the rods. Quadrupole mass spectrometers are available in a variety of formats, including a single quadrupole mass spectrometer, a triple quadrupole MS (three quadrupoles arranged in tandem), and a Q-TOF (a triple quad variant in which the third quadrupole is replaced with a time-of-flight mass analyzer).
Quadrupole mass analyzers are often used for targeted, quantitative applications and can be used either to measure one or a few given ions in a mixture, or to scan across a range of m/z values. Depending on the configuration, they can facilitate both MS and MS/MS applications. For instance, in a triple-quadrupole mass spectrometer, you can select ions for analysis in the first quadrupole, fragment them by collision with a gas in the second quadrupole, and analyze the resulting fragmentation ions in the third quadrupole.
Find, compare, and request a quote for quadrupole mass spectrometers across leading suppliers at Labcompare; including access to product citations, related published figures, and first-hand reviews from our scientific community.
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Company | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific |
Item | Thermo Scientific™ ISQ™ EC Single Quadrupole Mass Spectrometer | Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ Mass Spectrometer | Thermo Scientific™ Exactive™ Plus EMR Orbitrap™ LC-MS System | Thermo Scientific™ ISQ™ 7610 Single Quadrupole GC-MS System | Thermo Scientific™ ISQ™ EM Single Quadrupole Mass Spectrometer |
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Catalog Number | IQLAAAGADIFZZZMZZZ | IQLAAEGAAPFALGMAZR | IQLAAEGAAPFALGMBDL | IQLAAAGAAJFALOMBNA | IQLAAAGADIFZZZMZZZ |
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Ionization Method(s) | API, HESI | Inquire | APCI, H-ESI | EI, FS, SIM, FS/SIM, CI, PCI, NCI, depending on model | Atmospheric pressure ionization (API) source with interchangeable HESI and APCI probes |
Mass Analyzer | Single quadrupole | UHMR Hybrid Quadrupole-Orbitrap™ | Orbitrap | Triple off-axis Thermo Scientific™ DynaMax™ XTEND XR detection system, with off-axis 10 kV dynode, discrete dynode electron multiplier and electrometer, linear from 0 to 110 µA | Single quadrupole |
Scanning Speed | Up to 20,000 Da/sec. | up to 12 Hz at resolution setting of 12,500 at m/z 400 | Up to 12 Hz | Inquire | Up to 20,000 Da/sec. |
Mass Range | 10 to 1250 m/z | 350 to 80,000 m/z | 350 to 20,000 m/z | 1.2–1100 u with Unit Mass Resolution | 10 to 2000 m/z with Unit Mass Resolution |
Description | Add mass spectrometry (MS) to your IC and LC analyses for access to the valuable data that only MS can provide. The new, easy-to-use Thermo Scientific™ ISQ™ EC Single Quadrupole Mass Spectrometer seamlessly integrates with ion chromatography (IC) and high performance liquid chromatography (HPLC) Add mass spectrometry (MS) to your IC and LC analyses for access to the valuable data that only MS can provide. The new, easy-to-use Thermo Scientific™ ISQ™ EC Single Quadrupole Mass Spectrometer seamlessly integrates with ion chromatography (IC) and high performance liquid chromatography (HPLC) systems.... Read More | The Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ mass spectrometer is the first to provide the unique combination of unprecedented ultra-high mass range resolution, highest sensitivity, and MS2 and pseudo-MS3 capabilities needed to go beyond what’s possible with today’s native MS The Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ mass spectrometer is the first to provide the unique combination of unprecedented ultra-high mass range resolution, highest sensitivity, and MS2 and pseudo-MS3 capabilities needed to go beyond what’s possible with today’s native MS experiments.... Read More | While analysis of denatured proteins may be the most common LC/MS protein analysis, many biopharmaceutical and biological research applications require analysis of proteins in their native (intact) state. The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines unsurpassed high-While analysis of denatured proteins may be the most common LC/MS protein analysis, many biopharmaceutical and biological research applications require analysis of proteins in their native (intact) state. The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines unsurpassed high-resolution accurate-mass Thermo Scientific™ Orbitrap™ analysis with an extended mass range (EMR) option to create an outstanding tool for investigating the structure, topology, and architecture of native-like tertiary and quaternary protein structures.... Read More | Developed to enhance user experience in their workflows, the ISQ 7610 GC-MS system is streamlined to ensure great data consistency over time while offering automated instrument control tools. | Adding mass spectrometry (MS) to your liquid chromatography (LC) analyses gives you access to the valuable data that only MS can provide. The new, easy-to-use ISQ™ EM Single Quadrupole Mass Spectrometer seamlessly integrates with LC systems for reliable, robust, and easy LC-MS routine analysis with Adding mass spectrometry (MS) to your liquid chromatography (LC) analyses gives you access to the valuable data that only MS can provide. The new, easy-to-use ISQ™ EM Single Quadrupole Mass Spectrometer seamlessly integrates with LC systems for reliable, robust, and easy LC-MS routine analysis with an extended mass range for more flexibility. Detect and quantify a variety of analytes by choosing to use either heated electrospray ionization (HESI) or atmospheric pressure chemical ionization (APCI). Integrated software allows both novices and experts to quickly master MS to gain more insights from every sample.... Read More |
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