Quadrupole mass spectrometers are perhaps the simplest of mass spec instruments. Functioning effectively like a radio, the quadrupole MS – so-named because of its four charged rods, which run parallel to the flight paths of the ions it measures – filter ions by mass-to-charge ratio (m/z) by altering the voltages in the rods. Quadrupole mass spectrometers are available in a variety of formats, including a single quadrupole mass spectrometer, a triple quadrupole MS (three quadrupoles arranged in tandem), and a Q-TOF (a triple quad variant in which the third quadrupole is replaced with a time-of-flight mass analyzer).
Quadrupole mass analyzers are often used for targeted, quantitative applications and can be used either to measure one or a few given ions in a mixture, or to scan across a range of m/z values. Depending on the configuration, they can facilitate both MS and MS/MS applications. For instance, in a triple-quadrupole mass spectrometer, you can select ions for analysis in the first quadrupole, fragment them by collision with a gas in the second quadrupole, and analyze the resulting fragmentation ions in the third quadrupole.
Find, compare, and request a quote for quadrupole mass spectrometers across leading suppliers at Labcompare; including access to product citations, related published figures, and first-hand reviews from our scientific community.
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Company | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific |
Item | Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ Mass Spectrometer | Orbitrap Astral Mass Spectrometer | Thermo Scientific™ ISQ™ 7610 Single Quadrupole GC-MS System | Thermo Scientific™ ISQ™ EC Single Quadrupole Mass Spectrometer | Thermo Scientific™Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ LC-MS/MS Mass Spectrometer |
Citations | | | | | |
Catalog Number | IQLAAEGAAPFALGMAZR | Orbitrap Astral Mass Spectrometer | IQLAAAGAAJFALOMBNA | IQLAAAGADIFZZZMZZZ | IQLAAEGAAPFALGMBDK |
Price | | | | | |
Ionization Method(s) | Inquire | Adjustable heated electrospray ionization (HESI) probe | EI, FS, SIM, FS/SIM, CI, PCI, NCI, depending on model | API, HESI | APCI, H-ESI |
Mass Analyzer | UHMR Hybrid Quadrupole-Orbitrap™ | Orbitrap mass analyzer ranging from 7,500 to 480,000 resolution at m/z 200
Astral mass analyzer is operated at a single resolution setting of 80,000 at m/z 524 | Triple off-axis Thermo Scientific™ DynaMax™ XTEND XR detection system, with off-axis 10 kV dynode, discrete dynode electron multiplier and electrometer, linear from 0 to 110 µA | Single quadrupole | Hybrid Quadrupole / Orbitrap |
Scanning Speed | up to 12 Hz at resolution setting of 12,500 at m/z 400 | Up to 200 Hz | Inquire | Up to 20,000 Da/sec. | Up to 12 Hz |
Mass Range | 350 to 80,000 m/z | Maximum Astral mass analyzer resolution up to 80,000 FWHM at m/z 524
Maximum Orbitrap mass analyzer resolution of up to 480,000 FWHM at m/z 200 | 1.2–1100 u with Unit Mass Resolution | 10 to 1250 m/z | 50 to 6,000 m/z |
Description | The Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ mass spectrometer is the first to provide the unique combination of unprecedented ultra-high mass range resolution, highest sensitivity, and MS2 and pseudo-MS3 capabilities needed to go beyond what’s possible with today’s native MS The Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ mass spectrometer is the first to provide the unique combination of unprecedented ultra-high mass range resolution, highest sensitivity, and MS2 and pseudo-MS3 capabilities needed to go beyond what’s possible with today’s native MS experiments.... Read More | Inquire | Developed to enhance user experience in their workflows, the ISQ 7610 GC-MS system is streamlined to ensure great data consistency over time while offering automated instrument control tools. | Add mass spectrometry (MS) to your IC and LC analyses for access to the valuable data that only MS can provide. The new, easy-to-use Thermo Scientific™ ISQ™ EC Single Quadrupole Mass Spectrometer seamlessly integrates with ion chromatography (IC) and high performance liquid chromatography (HPLC) Add mass spectrometry (MS) to your IC and LC analyses for access to the valuable data that only MS can provide. The new, easy-to-use Thermo Scientific™ ISQ™ EC Single Quadrupole Mass Spectrometer seamlessly integrates with ion chromatography (IC) and high performance liquid chromatography (HPLC) systems.... Read More | Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased performance and new options that enhance applications from confident DMPK qual/quan screening studies to characterization of intact monoclonal antibodies.
Features: - Advanced Quadrupole technology featuring Thermo Fisher segmented HyperQuad
- Resolving power up to 280,000
- Maximum scan speed 12 Hz
- Spectral multiplexing for enhanced duty cycle
- RF-Lens ion source for increased sensitivity
- Advanced Active Beam Guide intelligent ion beam management for high flux ion sources
- Intact Protein Mode option for characterizing intact proteins with ease
- Enhanced Resolution Option maximizing resolution at 280,000
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