Quadrupole mass spectrometers are perhaps the simplest of mass spec instruments. Functioning effectively like a radio, the quadrupole MS – so-named because of its four charged rods, which run parallel to the flight paths of the ions it measures – filter ions by mass-to-charge ratio (m/z) by altering the voltages in the rods. Quadrupole mass spectrometers are available in a variety of formats, including a single quadrupole mass spectrometer, a triple quadrupole MS (three quadrupoles arranged in tandem), and a Q-TOF (a triple quad variant in which the third quadrupole is replaced with a time-of-flight mass analyzer).
Quadrupole mass analyzers are often used for targeted, quantitative applications and can be used either to measure one or a few given ions in a mixture, or to scan across a range of m/z values. Depending on the configuration, they can facilitate both MS and MS/MS applications. For instance, in a triple-quadrupole mass spectrometer, you can select ions for analysis in the first quadrupole, fragment them by collision with a gas in the second quadrupole, and analyze the resulting fragmentation ions in the third quadrupole.
Find, compare, and request a quote for quadrupole mass spectrometers across leading suppliers at Labcompare; including access to product citations, related published figures, and first-hand reviews from our scientific community.
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Company | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific | Thermo Fisher Scientific |
Item | Thermo Scientific™ ISQ™ EM Single Quadrupole Mass Spectrometer | Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ Mass Spectrometer | Thermo Scientific™ ISQ™ 7610 Single Quadrupole GC-MS System | Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer | TSQ Altis™ MD Mass Spectrometer |
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Catalog Number | IQLAAAGADIFZZZMZZZ | IQLAAEGAAPFALGMAZR | IQLAAAGAAJFALOMBNA | IQLAAEGAAPFADBMBHQ | IQLAAEGAAXFAQSMBLC |
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Ionization Method(s) | Atmospheric pressure ionization (API) source with interchangeable HESI and APCI probes | Inquire | EI, FS, SIM, FS/SIM, CI, PCI, NCI, depending on model | HESI | Inquire |
Mass Analyzer | Single quadrupole | UHMR Hybrid Quadrupole-Orbitrap™ | Triple off-axis Thermo Scientific™ DynaMax™ XTEND XR detection system, with off-axis 10 kV dynode, discrete dynode electron multiplier and electrometer, linear from 0 to 110 µA | Orbitrap | Triple quadrupole |
Scanning Speed | Up to 20,000 Da/sec. | up to 12 Hz at resolution setting of 12,500 at m/z 400 | Inquire | Inquire | Inquire |
Mass Range | 10 to 2000 m/z with Unit Mass Resolution | 350 to 80,000 m/z | 1.2–1100 u with Unit Mass Resolution | m/z 50–2,000
m/z 200–4,000
up to m/z 6,000 without precursor ion selection (OTMS only) | 5 to 3000 m/z |
Description | Adding mass spectrometry (MS) to your liquid chromatography (LC) analyses gives you access to the valuable data that only MS can provide. The new, easy-to-use ISQ™ EM Single Quadrupole Mass Spectrometer seamlessly integrates with LC systems for reliable, robust, and easy LC-MS routine analysis with Adding mass spectrometry (MS) to your liquid chromatography (LC) analyses gives you access to the valuable data that only MS can provide. The new, easy-to-use ISQ™ EM Single Quadrupole Mass Spectrometer seamlessly integrates with LC systems for reliable, robust, and easy LC-MS routine analysis with an extended mass range for more flexibility. Detect and quantify a variety of analytes by choosing to use either heated electrospray ionization (HESI) or atmospheric pressure chemical ionization (APCI). Integrated software allows both novices and experts to quickly master MS to gain more insights from every sample.... Read More | The Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ mass spectrometer is the first to provide the unique combination of unprecedented ultra-high mass range resolution, highest sensitivity, and MS2 and pseudo-MS3 capabilities needed to go beyond what’s possible with today’s native MS The Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ mass spectrometer is the first to provide the unique combination of unprecedented ultra-high mass range resolution, highest sensitivity, and MS2 and pseudo-MS3 capabilities needed to go beyond what’s possible with today’s native MS experiments.... Read More | Developed to enhance user experience in their workflows, the ISQ 7610 GC-MS system is streamlined to ensure great data consistency over time while offering automated instrument control tools. | Excel at the most challenging of applications, including low level PTM analysis, multiplexed relative quantitation using isobaric tags, intact protein characterization, as well as MSn analysis of small molecules with the new Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer. ThisExcel at the most challenging of applications, including low level PTM analysis, multiplexed relative quantitation using isobaric tags, intact protein characterization, as well as MSn analysis of small molecules with the new Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer. This system incorporates the brightest ion source, a segmented quadrupole mass filter with improved selectivity and ion transmission, Advanced Vacuum Technology for improved ion transmission to the Thermo Scientific™ Orbitrap™ mass analyzer, and ETD HD, a higher-capacity ETD fragmentation. Latest innovations include the Advanced Peak Determination (APD) algorithm for improved data-dependent experiments and two new hardware options: UVPD, a new fragmentation technique achieved with a 213 nm UV laser and 1M, which provides 1,000,000 FWHM ultra-high resolution for improved structural elucidation and quantitation of isobaric compounds.... Read More | Achieve the sensitivity to perform routine quantitative analyses with remarkable speed and robustness. The Thermo Scientific™ TSQ Quantis™ MD Series mass spectrometer can be used by clinical diagnostic laboratories to meet their routine requirements for laboratory developed tests (LDTs). With ActiveAchieve the sensitivity to perform routine quantitative analyses with remarkable speed and robustness. The Thermo Scientific™ TSQ Quantis™ MD Series mass spectrometer can be used by clinical diagnostic laboratories to meet their routine requirements for laboratory developed tests (LDTs). With Active Ion Management (AIM+) technology,the TSQ Quantis MD Series delivers confident quantitation for routine analyses of human specimens.... Read More |
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