Triple Quadrupole Mass Spectrometer (QqQ MS)

A triple-quadrupole mass spectrometer, also known as QqQ, is a tandem MS method in which the first and third quadrupoles act as mass filters and the second causes fragmentation of the analyte through interaction with a collision gas—it is a radiofrequency-only quadrupole, and can be used in either SIM or scan mode. The method can be used to obtain structural information or for quantitation. For structural mass spec, a common sequence is product ion scan, precursor ion scan, and neutral loss scan, followed by selected reaction monitoring (SRM) or multiple reaction monitoring (MRM). Increased selectivity, improved S/N, lower limits of quantitation, wider linear range, and improved accuracy are some of the benefits of this technique, which encompasses triple-quad LC-MS, GC-MS, GC-MSD, and ICP-MS. Although QqQ is a particularly useful method for all stages of pharmaceutical development, it is a reliable option for many applications, such as clinical research, food safety, forensics, environmental, and proteomics.

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CompanyShimadzuShimadzuShimadzuShimadzu
ItemLCMS-8050 Triple Quadrupole LC/MS/MS Mass SpectrometerLCMS-8045 Triple Quadrupole LC/MS/MS Mass SpectrometerLCMS-8060 NX Triple Quadrupole LC/MS/MS Mass SpectrometerLCMS-8060 Triple Quadrupole LC/MS/MS Mass Spectrometer
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Catalog NumberLCMS-8050LCMS-8045LCMS-8060 NXLCMS-8060
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DescriptionIncorporating Shimadzu’s proprietary ultrafast technologies (UF Technologies), the triple quadrupole LCMS-8050 offers outstanding measurement speeds and quantitative performance. Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated ... Read MoreThe workhorse triple quad LCMS-8045 is designed to analyze samples around the clock, making it the perfect option for production laboratories. The heated ESI probe, high-temperature heating block, heated desolvation line, drying gas, and focusing optics all act to maximize sensitivity while ... Read MoreShimadzu's most powerful tandem mass spectrometer, the triple quad LCMS-8060NX utilizes proprietary technologies and more efficient ion transfer to achieve outstanding speed and sensitivity. Incorporation of a new IonFocus electrospray unit and newly designed ion guides deliver robust operation ... Read MoreWith improved ion focusing technology, and incorporating Shimadzu’s proprietary ultrafast technologies, the LCMS-8060 creates a meaningful impact on trace quantitative detection. Combined with a robust design and easy maintenance, the LCMS-8060 is an ideal solution for better data quality and higher... Read More
Ionization Method(s)ESI, APCI, Dual IonizationHeated ESI ProbeESI probe with focus electrodesESI, APCI, Dual Ionization
Mass AnalyzerQ1 & Q3 are molybdenum hyperbolic mass filters with pre-rods; Q1 includes post-rodsTriple quadrupoleTriple quadrupoleQ1 & Q3 are molybdenum hyperbolic mass filters with pre-rods; Q1 includes post-rods
Mass Range2 to 2000 m/zm/z 2 to 2,000m/z 2 to 2,0002 to 2000 m/z
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