LC MS Instrument

Comprising two components, a liquid-phase separation system and a mass spectrometer, liquid chromatograph mass spectrometers (LC MS instruments) couple sample fractionation and analysis. The separation can be accomplished via standard liquid chromatography, HPLC, UPLC, or even nano-LC. Any liquid-phase separation will do, so long as its output can be directed into the mass analyzer (for instance, via an electrospray ionization source). The mass spectrometer is similarly flexible, ranging from the simplest single quadrupole to a Fourier transform ion cyclotron resonance instrument. Just remember, in a liquid chromatograph mass spectrometer the column flow is continuous, meaning the mass analyzer must be fast enough to thoroughly analyze one peak before the next one comes off the column. And, unlike with MALDI MS, once a peak is analyzed, it’s gone.
CompanySCIEXSCIEXSCIEXSCIEXSCIEX
ItemX500R QTOF systemIntabio ZT systemSCIEX Triple Quad 7500 systemSelexION Differential Mobility SpectrometryZenoTOF 7600 system
Citations
(1)
Catalog NumberX500R QTOFIntabio ZTSCIEX Triple Quad 7500SelexIONZenoTOF 7600
Price
Ionization Method(s)Turbo V ion source with twin sprayer ESI probe
and twin sprayer APCI probe
InquireOptiFlow® Pro Ion SourceInquireAPCI and ESI modes
Mass AnalyzerQTOFInquireTriple quadrupoleInquireTOF
Scanning SpeedUp to 25 Hz (25 spectra per second)Inquire20,000 Da/sInquireup to 25 Hz (25 spectra per second)
ResolutionEqual to or greater than 42,000 (FWHM) measured on the (M+6H)6+ charge isotope cluster for bovine insulin at m/z 956InquireUp to 3100 for mass 922 in LIT mode 1000 Da/s (0.3 Da)
Tune to a peak width of 0.5 Da for TQ mode
InquireEqual to or greater than 42,000 (FWHM) measured on the [M+6H]6+ charge isotope cluster for bovine insulin at m/z 956
DescriptionEngineered for standard biotherapeutic characterization analyses, the X500B QTOF system is a true benchtop instrument, with streamlined processing to get to a consistent, accurate view of your biologic. It is optimized for intact mass analysis, subunit analysis as well as high-quality peptide ... Read MoreThe Intabio ZT system couples icIEF separation and UV detection with high-resolution mass spectrometry on the ZenoTOF 7600 system. Experience one integrated workflow with a single, accessible dataset containing the required information to make the right decisions, fast.

Features
  • Comprehensive
... Read More
Incomparable: Experience extraordinary sensitivity gains from the SCIEX 7500 system. Start detecting the previously undetectable, and quantify at lower levels with impressive precision.

Ingenious: Expand your laboratory capabilities to test dirty and complex samples. The new D Jet ion guide will
... Read More
LC-MS/MS assay development can be challenging, particularly for analytes that coelute with contaminants or become buried within background noise. The SCIEX SelexION Differential Mobility Separation device (DMS) provides an extra level of selectivity so you can resolve difficult analytes and achieve ... Read MoreA powerful leap in proprietary innovation, this high-resolution accurate mass system combines the power of Zeno trap pulsing with EAD fragmentation technology (electron activated dissociation) to uncover structural information, previously inaccessible, and drive the limits of quantification ... Read More
QuantityEAEAEAInquireEA
TypeInquireInquireLC-MS/MSInquireInquire
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