LC MS Instrument

Comprising two components, a liquid-phase separation system and a mass spectrometer, liquid chromatograph mass spectrometers (LC MS instruments) couple sample fractionation and analysis. The separation can be accomplished via standard liquid chromatography, HPLC, UPLC, or even nano-LC. Any liquid-phase separation will do, so long as its output can be directed into the mass analyzer (for instance, via an electrospray ionization source). The mass spectrometer is similarly flexible, ranging from the simplest single quadrupole to a Fourier transform ion cyclotron resonance instrument. Just remember, in a liquid chromatograph mass spectrometer the column flow is continuous, meaning the mass analyzer must be fast enough to thoroughly analyze one peak before the next one comes off the column. And, unlike with MALDI MS, once a peak is analyzed, it’s gone.
CompanyThermo Fisher ScientificThermo Fisher ScientificThermo Fisher ScientificThermo Fisher ScientificThermo Fisher Scientific
ItemThermo Scientific™Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ LC-MS/MS Mass SpectrometerQ Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ Mass SpectrometerThermo Scientific™ Exactive™ Plus EMR Orbitrap™ LC-MS SystemThermo Scientific™ Orbitrap Exploris™ 240 Mass SpectrometerThermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer
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Catalog NumberIQLAAEGAAPFALGMBDKIQLAAEGAAPFALGMAZRIQLAAEGAAPFALGMBDLIQLAAEGAAPFARBMBKPIQLAAEGAAPFADBMBHQ
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Ionization Method(s)APCI, H-ESIInquireAPCI, H-ESIInquireHESI
Mass AnalyzerHybrid Quadrupole / OrbitrapUHMR Hybrid Quadrupole-Orbitrap™OrbitrapInquireOrbitrap
Scanning SpeedUp to 12 Hzup to 12 Hz at resolution setting of 12,500 at m/z 400Up to 12 HzInquireInquire
Resolutionup to 280,000 FWHM200,000 at m/z 400up to 140,000 FWHMInquire7500-500,000 (FWHM) at m/z 200
DescriptionTake Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased ... Read MoreThe Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole-Orbitrap™ mass spectrometer is the first to provide the unique combination of unprecedented ultra-high mass range resolution, highest sensitivity, and MS2 and pseudo-MS3 capabilities needed to go beyond what’s possible with today’s native MS ... Read MoreWhile analysis of denatured proteins may be the most common LC/MS protein analysis, many biopharmaceutical and biological research applications require analysis of proteins in their native (intact) state. The Thermo Scientific™ Exactive™ Plus EMR mass spectrometer combines unsurpassed high-... Read MoreThe Thermo Scientific Orbitrap Exploris 240 mass spectrometer combines application flexibility with the performance to drive discovery and identification, plus receive the quantitative precision and accuracy you need to confidently scale up and achieve impact. With operational simplicity through ... Read MoreExcel at the most challenging of applications, including low level PTM analysis, multiplexed relative quantitation using isobaric tags, intact protein characterization, as well as MSn analysis of small molecules with the new Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer. This... Read More
QuantityEAEAEAEAEA
TypeInquireQuadrupole-Orbitrap LC-MSInquireMass SpectrometerInquire
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