| Description | Hudson’s integrated screening workcell is designed to provide quick and accurate profiling of ADME and toxicological properties of drug molecules. The basic system contains everything needed to support biochemical assays that measure physicochemical properties of drug molecules, such as solubility, Hudson’s integrated screening workcell is designed to provide quick and accurate profiling of ADME and toxicological properties of drug molecules. The basic system contains everything needed to support biochemical assays that measure physicochemical properties of drug molecules, such as solubility, lipophilicity, pKa and protein binding, and also supports PAMPA and CACO2 permeability assays. It also can measure a drug’s affinity towards key toxicological targets, such as hERG, and the various CYP metabolic enzymes.
The system is controlled by Hudson’s SoftLinx scheduling software, and comes with sample protocols for each of the included ADME/Tox methods. These can be easily modified, or more assays can be added to further customize your follow-up screening efforts. The system comes with a multi-mode reader that not only supports a wide range of protocols, but can also run your primary or secondary screens. This means that you can have your ADME/Tox profiling automatically carried out on hits found in these assays.... Read More | The VaryScreen integrates laboratory instrumentation with plate and liquid handling robots and software to automate all aspects of an assay. The basic configuration includes a multimode microplate reader with fluorescence, luminescence, and UV-Visible detectors. The system’s SoftLinx software The VaryScreen integrates laboratory instrumentation with plate and liquid handling robots and software to automate all aspects of an assay. The basic configuration includes a multimode microplate reader with fluorescence, luminescence, and UV-Visible detectors. The system’s SoftLinx software controls all of the robot’s actions in an efficient, coordinated operation.
One System Performs Six of the Most Common Assays - Fluorescence Intensity
- Fluorescence Polarization
- FRET (and variations e.g., LANCE and VIPER)
- Luminescence (e.g., Luciferase Reporter)
- ELISA
- AlphaScreen
There’s no need to purchase several dedicated systems for each assay type. Now there’s a workcell that lets you shift from one type of assay to another. The VaryScreen performs six of the most common biological assays conducted today with pre-defined protocols below. And you can introduce countless variations with just a few user-friendly software modifications. Speed up Assay Development, Validation and Execution
The VaryScreen makes it easy to evaluate the impact of various changes in assay conditions to develop, model and validate your in-house screens.... Read More |
| Assays | Solubility, Lipophilicity, pKa, Protein Binding, PAMPA and CACO2 Permeability Assays, hERG Affinitey and CYP Metabolic Enzymes | UV-VIS Absorption, Fluorescence Polarization, FRET (LANCE, VIPER), Luminescence (Reporter Assays), ELISA and Alpha Screen |